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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfsf11tles
toothless
MGI:5307891
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnfsf11tles/Tnfsf11tles involves: 129S6/SvEvTac * C57BL/6J MGI:5307894
ht2
Tnfsf11tles/Tnfsf11tm1Pngr involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J MGI:5307895
cx3
Tg(TNFSF11)5516Edou/0
Tnfsf11tles/Tnfsf11tles
involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5788434
cx4
Tg(TNFSF11)5519Edou/0
Tnfsf11tles/Tnfsf11tles
involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5788435


Genotype
MGI:5307894
hm1
Allelic
Composition
Tnfsf11tles/Tnfsf11tles
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf11tles mutation (2 available); any Tnfsf11 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in culture, osteoblasts fail to produce adequate crosstalk to promote differentiation of wild-type hematopoietic progenitors into osteoclasts

mortality/aging
• most mice die by the seventh week of age

skeleton
N
• bone marrow exposed to wild-type osteoblasts exhibits normal differentiation into osteoclasts
• in culture, osteoblasts fail to produce adequate crosstalk to promote differentiation of wild-type hematopoietic progenitors into osteoclasts
• absent
• however, treatment with TNFSF11 restores osteoclast formation
• trabecular spacing is reduced compared to in wild-type mice
• severe

immune system
• absent
• however, treatment with TNFSF11 restores osteoclast formation

growth/size/body

craniofacial

hematopoietic system
• absent
• however, treatment with TNFSF11 restores osteoclast formation

endocrine/exocrine glands

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive osteopetrosis 2 DOID:0110943 OMIM:259710
J:179743




Genotype
MGI:5307895
ht2
Allelic
Composition
Tnfsf11tles/Tnfsf11tm1Pngr
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf11tles mutation (2 available); any Tnfsf11 mutation (25 available)
Tnfsf11tm1Pngr mutation (0 available); any Tnfsf11 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• trabecular spacing is reduced compared to in wild-type mice
• severe

immune system

craniofacial

hematopoietic system

growth/size/body




Genotype
MGI:5788434
cx3
Allelic
Composition
Tg(TNFSF11)5516Edou/0
Tnfsf11tles/Tnfsf11tles
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TNFSF11)5516Edou mutation (0 available)
Tnfsf11tles mutation (2 available); any Tnfsf11 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• mice show rescue of lower incisor eruption but only partial rescue of upper incisor eruption

immune system
• mice show failure of lymph node organogenesis

growth/size/body
• mice show rescue of lower incisor eruption but only partial rescue of upper incisor eruption

mortality/aging
N
• mice exhibit normal survival

skeleton
N
• mice exhibit rescue of the osteopetrotic phenotype seen in single Tnfsf11tles homozygotes
• mice show rescue of lower incisor eruption but only partial rescue of upper incisor eruption




Genotype
MGI:5788435
cx4
Allelic
Composition
Tg(TNFSF11)5519Edou/0
Tnfsf11tles/Tnfsf11tles
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TNFSF11)5519Edou mutation (0 available)
Tnfsf11tles mutation (2 available); any Tnfsf11 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice exhibit complete rescue of the abnormal phenotypes seen in single Tnfsf11tles homozygotes, including rescue of the osteopetrotic phenotype, of both lower and upper incisor eruption defects and of mesenteric lymph node organogenesis





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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory