Phenotypes associated with this allele

• Allele Symbol: Slc4a5^tm1.1Boet
• Allele Name: targeted mutation 1, Thomas Boettger
• Allele ID: MGI:5306980
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc4a5^tm1.1Boet/Slc4a5^tm1.1Boet	involves: 129 * C57BL/6	MGI:5306985

Genotype
MGI:5306985

hm1

• Allelic Composition: Slc4a5^tm1.1Boet/Slc4a5^tm1.1Boet
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:180608 )

• mice exhibit decreased total carbon dioxide and reduced base excess of extracellular fluid compared with wild-type mice

decreased circulating creatinine level ( J:180608 )

decreased circulating bicarbonate level ( J:180608 )

increased circulating atrial natriuretic factor ( J:180608 )

decreased circulating aldosterone level ( J:180608 )

decreased circulating renin level ( J:180608 )

renal tubular acidosis ( J:180608 )

• renal metabolic acidosis indicated by decreased total carbon dioxide

abnormal urine homeostasis ( J:180608 )

• due to increased daily urinary volume, electrolyte excretion is slightly increased compared with wild-type mice

increased urine bicarbonate level ( J:180608 )

increased urine protein level ( J:180608 )

renal/urinary system

renal tubular acidosis ( J:180608 )

• renal metabolic acidosis indicated by decreased total carbon dioxide

abnormal urine homeostasis ( J:180608 )

• due to increased daily urinary volume, electrolyte excretion is slightly increased compared with wild-type mice

increased urine bicarbonate level ( J:180608 )

increased urine protein level ( J:180608 )

delayed kidney development ( J:180608 )

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increased renal glomerular filtration rate ( J:180608 )

polyuria ( J:180608 )

cardiovascular system

increased systemic arterial diastolic blood pressure ( J:180608 )

• at night and during the day under normal conditions

• under induced metabolic alkalosis by ammoniumchloride administration

• however, mice exhibit normal blood pressure in response to under induced metabolic alkalosis by sodium bicarbonate administration

increased systemic arterial systolic blood pressure ( J:180608 )

• at night and during the day under normal conditions

• under induced metabolic alkalosis by ammoniumchloride administration

• however, mice exhibit normal blood pressure in response to under induced metabolic alkalosis by sodium bicarbonate administration

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:180608 )

N • mice exhibit normal thyroid function

nervous system

nervous system phenotype ( J:180608 )

N • unlike mice homozygous for a Slc4a5 gene trap allele, brain ventricles are normal