All Phenotypes Casr<tm1Wch> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Casr^tm1Wch
targeted mutation 1, Wenhan Chang
MGI:5306665

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Casr^tm1Wch/Casr^tm1Wch Tg(Col1a1-cre)2Bek/0	involves: 129S4/SvJae * C57BL/6 * CD-1	MGI:5306891
cn2	Casr^tm1Wch/Casr^tm1Wch Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129S4/SvJae * C57BL/6 * CD-1	MGI:5306892
cn3	Casr^tm1Wch/Casr⁺ Tg(PTH-cre)4167Slib/0	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:5306890
cn4	Casr^tm1Wch/Casr^tm1Wch Tg(PTH-cre)4167Slib/0	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:5306889
cn5	Casr^tm1Wch/Casr^tm1Wch Tg(Col2a1-cre/ERT)KA3Smac/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5306894
cn6	Casr^tm1Wch/Casr^tm1Wch Tg(Vil1-cre)997Gum/0	involves: 129S4/SvJae * C57BL/6J * SJL	MGI:5306895
cn7	Casr^tm1Wch/Casr^tm1Wch Tg(Col2a1-cre)1Bhr/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5306893

Allelic Composition	Casr^tm1Wch/Casr^tm1Wch Tg(Col1a1-cre)2Bek/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casr^tm1Wch mutation (0 available); any Casr mutation (55 available)
Tg(Col1a1-cre)2Bek mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:180651 )

• mice die within 3 weeks of birth

skeleton

abnormal skeleton morphology ( J:180651 )

• small, fragile, and undermineralized skeleton

decreased bone mineral density ( J:180651 )

decreased compact bone volume ( J:180651 )

decreased compact bone thickness ( J:180651 )

abnormal trabecular bone morphology ( J:180651 )

• mice exhibit increased trabecular spacing compared with control mice

decreased trabecular bone volume ( J:180651 )

decreased bone trabecula number ( J:180651 )

decreased trabecular bone connectivity density ( J:180651 )

decreased trabecular bone thickness ( J:180651 )

abnormal skeleton development ( J:180651 )

• blocked

decreased bone mineralization ( J:180651 )

• undermineralized skeleton

fragile skeleton ( J:180651 )

growth/size/body

decreased body size ( J:180651 )

• at 7 day and 21 days

decreased body weight ( J:180651 )

postnatal growth retardation ( J:180651 )

• blocked

Allelic Composition	Casr^tm1Wch/Casr^tm1Wch Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casr^tm1Wch mutation (0 available); any Casr mutation (55 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:180651 )

N	• mice exhibit normal cortical bone thickness

decreased compact bone volume ( J:180651 )

abnormal trabecular bone morphology ( J:180651 )

• mice exhibit increased trabecular spacing compared with control mice

decreased trabecular bone volume ( J:180651 )

decreased bone trabecula number ( J:180651 )

decreased trabecular bone connectivity density ( J:180651 )

decreased trabecular bone thickness ( J:180651 )

abnormal skeleton development ( J:180651 )

• blocked, reduced bone formation

decreased bone mineralization ( J:180651 )

• undermineralized skeleton

growth/size/body

decreased body size ( J:180651 )

postnatal growth retardation ( J:180651 )

• blocked

Allelic Composition	Casr^tm1Wch/Casr⁺ Tg(PTH-cre)4167Slib/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casr^tm1Wch mutation (0 available); any Casr mutation (55 available)
Tg(PTH-cre)4167Slib mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:180651 )

N	• mice exhibit normal trabecular bone connectivity density and trabeculae spacing

decreased bone mineral density ( J:180651 )

• mild by 6 months of age

decreased compact bone volume ( J:180651 )

decreased compact bone thickness ( J:180651 )

decreased bone trabecula number ( J:180651 )

decreased trabecular bone thickness ( J:180651 )

homeostasis/metabolism

increased circulating parathyroid hormone level ( J:180651 )

increased circulating calcium level ( J:180651 )

increased urine calcium level ( J:180651 )

renal/urinary system

increased urine calcium level ( J:180651 )

Allelic Composition	Casr^tm1Wch/Casr^tm1Wch Tg(PTH-cre)4167Slib/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casr^tm1Wch mutation (0 available); any Casr mutation (55 available)
Tg(PTH-cre)4167Slib mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:180651 )

• mice die within 2 weeks of birth

skeleton

abnormal skeleton morphology ( J:180651 )

• small, fragile, and undermineralized skeleton

decreased bone mineral content ( J:180651 )

• in trabecular and cortical bones

decreased bone mineral density ( J:180651 )

abnormal skeleton development ( J:180651 )

• retarded

decreased bone mineralization ( J:180651 )

• undermineralized skeleton

fragile skeleton ( J:180651 )

homeostasis/metabolism

increased circulating parathyroid hormone level ( J:180651 )

increased circulating calcium level ( J:180651 )

increased urine calcium level ( J:180651 )

renal/urinary system

increased urine calcium level ( J:180651 )

growth/size/body

decreased body weight ( J:180651 )

postnatal growth retardation ( J:180651 )

• growth is severely blunted

Allelic Composition	Casr^tm1Wch/Casr^tm1Wch Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casr^tm1Wch mutation (0 available); any Casr mutation (55 available)
Tg(Col2a1-cre/ERT)KA3Smac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton development ( J:180651 )

• tamoxifen-treated mice exhibit reduced skeleton length compared with control mice

increased width of hypertrophic chondrocyte zone ( J:180651 )

• in tamoxifen-treated mice

decreased bone mineralization ( J:180651 )

• decreased mineralization in tamoxifen-treated mice

Allelic Composition	Casr^tm1Wch/Casr^tm1Wch Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129S4/SvJae * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casr^tm1Wch mutation (0 available); any Casr mutation (55 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal enterocyte proliferation ( J:179672 )

• cell proliferation in colonic crypts is increased compared to in control mice

abnormal large intestine crypts of Lieberkuhn morphology ( J:179672 )

• colon crypt height and number of cells per crypt are increased compared to in control mice

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:179672 )

• colon crypt height and number of cells per crypt are increased compared to in control mice

cellular

abnormal enterocyte proliferation ( J:179672 )

• cell proliferation in colonic crypts is increased compared to in control mice

Allelic Composition	Casr^tm1Wch/Casr^tm1Wch Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casr^tm1Wch mutation (0 available); any Casr mutation (55 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:180651 )

• no mice are detected between E14 and E16

embryonic lethality during organogenesis, incomplete penetrance ( J:180651 )

• only 2 mice are detected between E12 and E13

skeleton

abnormal skeleton development ( J:180651 )

• at E12.5, the two surviving mice exhibit short skeletons compared with control mice

decreased bone mineralization ( J:180651 )

• mice exhibit poorly mineralized rib cages, calvariae, and long bones compared with control mice

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