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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trp53tm1.1Dgk
targeted mutation 1.1, David G Kirsch
MGI:5306612
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Trp53tm1Tyj/Trp53tm1.1Dgk involves: 129S * 129X1/SvJ * C57BL/6 MGI:5306614
cn2
Krastm5Tyj/Kras+
Trp53tm1.1Dgk/Trp53tm1.1Dgk
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:5306615


Genotype
MGI:5306614
cn1
Allelic
Composition
Trp53tm1Tyj/Trp53tm1.1Dgk
Genetic
Background
involves: 129S * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1.1Dgk mutation (1 available); any Trp53 mutation (142 available)
Trp53tm1Tyj mutation (9 available); any Trp53 mutation (142 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus (J:180576)
• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus (J:180576)
• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus (J:180576)
• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus (J:180576)




Genotype
MGI:5306615
cn2
Allelic
Composition
Krastm5Tyj/Kras+
Trp53tm1.1Dgk/Trp53tm1.1Dgk
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm5Tyj mutation (2 available); any Kras mutation (30 available)
Trp53tm1.1Dgk mutation (1 available); any Trp53 mutation (142 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• lung tumors from mice injected with cre- and flpo-expressing adenoviruses exhibit a doubling time of 2 weeks (J:180576)
• lung tumors from mice injected with cre- and flpo-expressing adenoviruses exhibit a doubling time of 2 weeks (J:180576)
• high-grade ling adenocarcinomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses (J:180576)
• high-grade ling adenocarcinomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses (J:180576)
• extremity sarcomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses (J:180576)
• extremity sarcomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses (J:180576)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory