Mouse Genome Informatics
cn1
    Trp53tm1Tyj/Trp53tm1.1Dgk
involves: 129S * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus
• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus


Mouse Genome Informatics
cn2
    Krastm5Tyj/Kras+
Trp53tm1.1Dgk/Trp53tm1.1Dgk

involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• lung tumors from mice injected with cre- and flpo-expressing adenoviruses exhibit a doubling time of 2 weeks
• high-grade ling adenocarcinomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses
• extremity sarcomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses