Mouse Genome Informatics
cn1
    Trp53tm1Tyj/Trp53tm1.1Dgk
involves: 129S * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cellular
• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus
• in mouse embryonic fibroblasts transfected with a flpo-expressing adenovirus


Mouse Genome Informatics
cn2
    Rb1tm2Brn/Rb1tm2Brn
Trp53tm1.1Dgk/Trp53tm1.1Dgk

involves: 129 * 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• adenovirus-FLPe/IRES/Cre (Ad-FIC) induces a dose dependent increase in mortality with no mice surviving to 55 weeks post infection at concentrations greater than or equal to 5.00E+06 infectious units (iu)
• no mice survive to 40 weeks post infection when dosed with 5.00E+07 iu of Ad-FIC

tumorigenesis
• following infection with Ad-FIC
• early stage tumors are detected by 16 weeks post infection with Ad-FIC and late stage tumors are detected by about 32 weeks post infection

respiratory system
• neuroendocrine hyperplasia is detected at 8 weeks post infection with Ad-FIC

Mouse Models of Human Disease
OMIM IDRef(s)
Small Cell Cancer of the Lung 182280 J:187012


Mouse Genome Informatics
cn3
    Krastm4Tyj/Kras+
Trp53tm1.1Dgk/Trp53tm1.1Dgk

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• following infection with adenovirus-FLPe/IRES/Cre (Ad-FIC)
• following infection with Ad-FIC

Mouse Models of Human Disease
OMIM IDRef(s)
Lung Cancer 211980 J:187012


Mouse Genome Informatics
cn4
    Krastm5Tyj/Kras+
Trp53tm1.1Dgk/Trp53tm1.1Dgk

involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• lung tumors from mice injected with cre- and flpo-expressing adenoviruses exhibit a doubling time of 2 weeks
• high-grade ling adenocarcinomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses
• extremity sarcomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses