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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dscamtm1Pfu
targeted mutation 1, Peter G Fuerst
MGI:5305022
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dscamtm1Pfu/Dscamtm1Pfu
Opn4tm1(cre)Sapa/Opn4+ 		involves: 129 * C57BL/6 MGI:5305038
cn2
 		Dscamtm1Pfu/Dscamtm1Pfu
Tg(Pax6-cre,GFP)2Pgr/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5305027
cn3
 		Dscamtm1Pfu/Dscamtm1Pfu
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5305034
cn4
 		Dscamtm1Pfu/Dscamtm1Pfu
Tg(Thy1-cre)1Vln/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:5305037
cn5
 		Dscamtm1Pfu/Dscamtm1Pfu
Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/?
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5305036


Genotype
MGI:5305038
cn1
Allelic
Composition		 Dscamtm1Pfu/Dscamtm1Pfu
Opn4tm1(cre)Sapa/Opn4+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscamtm1Pfu mutation (1 available); any Dscam mutation (105 available)
Opn4tm1(cre)Sapa mutation (0 available); any Opn4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina ganglion cell morphology ( J:179393 )
• fasiculation and spacing phenotype in melanopsin positive RGCs

nervous system
abnormal axon fasciculation ( J:179393 )
• fasiculation and spacing phenotype in melanopsin positive RGCs
abnormal retina ganglion cell morphology ( J:179393 )
• fasiculation and spacing phenotype in melanopsin positive RGCs

cellular
abnormal axon fasciculation ( J:179393 )
• fasiculation and spacing phenotype in melanopsin positive RGCs




Genotype
MGI:5305027
cn2
Allelic
Composition		 Dscamtm1Pfu/Dscamtm1Pfu
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscamtm1Pfu mutation (1 available); any Dscam mutation (105 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal amacrine cell morphology ( J:179393 )
• dopaminergic amacrine cells and neurites are clumped
• disorganization is seen in all portions of the inner nuclear layer, even where cre is inactive
• cholinergic amacrine cell lamination is impaired in portions of the retina where cre is active in all retinal neurons
abnormal retina ganglion cell morphology ( J:179393 )
• melanopsin-positive RGCs are fasciculated and aggregated in the peripheral retina, but not in the central or dorsal retina

nervous system
abnormal axon fasciculation ( J:179393 )
• of retinal dopaminergic and bNOS positive amacrine cell neurites
abnormal amacrine cell morphology ( J:179393 )
• dopaminergic amacrine cells and neurites are clumped
• disorganization is seen in all portions of the inner nuclear layer, even where cre is inactive
• cholinergic amacrine cell lamination is impaired in portions of the retina where cre is active in all retinal neurons
abnormal retina ganglion cell morphology ( J:179393 )
• melanopsin-positive RGCs are fasciculated and aggregated in the peripheral retina, but not in the central or dorsal retina

cellular
abnormal axon fasciculation ( J:179393 )
• of retinal dopaminergic and bNOS positive amacrine cell neurites




Genotype
MGI:5305034
cn3
Allelic
Composition		 Dscamtm1Pfu/Dscamtm1Pfu
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscamtm1Pfu mutation (1 available); any Dscam mutation (105 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal amacrine cell morphology ( J:179393 )
• following tamoxifen treatment at E13 or E16 dopaminergic amacrine cells and neurites are clumped
increased amacrine cell number ( J:179393 )
• following tamoxifen treatment at P0
abnormal retina ganglion cell morphology ( J:179393 )
• following tamoxifen treatment at P0 2?3 fasciculated groups of melanopsin positive retinal ganglion cells are seen in each retina

nervous system
abnormal axon fasciculation ( J:179393 )
• following tamoxifen treatment at E13 or E16 dopaminergic amacrine cells and neurites are clumped
• following tamoxifen treatment at P0, 2?3 fasciculated groups of retinal ganglion cells are seen in each retina
• however with tamoxifen treatment at P0 or in adults no fasiculation of amacrine cell neurites is seen
abnormal amacrine cell morphology ( J:179393 )
• following tamoxifen treatment at E13 or E16 dopaminergic amacrine cells and neurites are clumped
increased amacrine cell number ( J:179393 )
• following tamoxifen treatment at P0
abnormal retina ganglion cell morphology ( J:179393 )
• following tamoxifen treatment at P0 2?3 fasciculated groups of melanopsin positive retinal ganglion cells are seen in each retina

cellular
abnormal axon fasciculation ( J:179393 )
• following tamoxifen treatment at E13 or E16 dopaminergic amacrine cells and neurites are clumped
• following tamoxifen treatment at P0, 2?3 fasciculated groups of retinal ganglion cells are seen in each retina
• however with tamoxifen treatment at P0 or in adults no fasiculation of amacrine cell neurites is seen




Genotype
MGI:5305037
cn4
Allelic
Composition		 Dscamtm1Pfu/Dscamtm1Pfu
Tg(Thy1-cre)1Vln/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscamtm1Pfu mutation (1 available); any Dscam mutation (105 available)
Tg(Thy1-cre)1Vln mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina ganglion cell morphology ( J:179393 )
• aggregation of recombined retinal ganglion cells

nervous system
abnormal retina ganglion cell morphology ( J:179393 )
• aggregation of recombined retinal ganglion cells




Genotype
MGI:5305036
cn5
Allelic
Composition		 Dscamtm1Pfu/Dscamtm1Pfu
Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/?
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscamtm1Pfu mutation (1 available); any Dscam mutation (105 available)
Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal amacrine cell morphology ( J:179393 )
• recombined but not non-recombined dopaminergic amacrine cells and neurites are clumped

nervous system
abnormal axon fasciculation ( J:179393 )
• recombined but not non-recombined dopaminergic amacrine cells and neurites are clumped
abnormal amacrine cell morphology ( J:179393 )
• recombined but not non-recombined dopaminergic amacrine cells and neurites are clumped

cellular
abnormal axon fasciculation ( J:179393 )
• recombined but not non-recombined dopaminergic amacrine cells and neurites are clumped




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory