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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Notch3tm1.1(cre/ERT2)Sat
targeted mutation 1.1, Spyros Artavanis-Tsakonas
MGI:5304914
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Notch3tm1.1(cre/ERT2)Sat/Notch3+ C57BL/6-Notch3tm1.1(cre/ERT2)Sat MGI:5304926
cn2
 		Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/Gt(ROSA)26Sortm1(Notch3*)Sfr
Notch3tm1.1(cre/ERT2)Sat/Notch3+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac MGI:5556107


Genotype
MGI:5304926
ht1
Allelic
Composition		 Notch3tm1.1(cre/ERT2)Sat/Notch3+
Genetic
Background		 C57BL/6-Notch3tm1.1(cre/ERT2)Sat
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch3tm1.1(cre/ERT2)Sat mutation (0 available); any Notch3 mutation (93 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:179632 )
• heterozygotes are viable and fertile




Genotype
MGI:5556107
cn2
Allelic
Composition		 Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/Gt(ROSA)26Sortm1(Notch3*)Sfr
Notch3tm1.1(cre/ERT2)Sat/Notch3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Notch3*)Sfr mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Notch3tm1.1(cre/ERT2)Sat mutation (0 available); any Notch3 mutation (93 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased mammary gland epithelial cell proliferation ( J:201985 )
• following 4 weeks of tamoxifen treatment clonal expansion of cre expressing cells is markedly reduced

cellular
decreased mammary gland epithelial cell proliferation ( J:201985 )
• following 4 weeks of tamoxifen treatment clonal expansion of cre expressing cells is markedly reduced

integument
decreased mammary gland epithelial cell proliferation ( J:201985 )
• following 4 weeks of tamoxifen treatment clonal expansion of cre expressing cells is markedly reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory