Phenotypes associated with this allele

• Allele Symbol: Ptpn2^tm1.1Ttig
• Allele Name: targeted mutation 1.1, Tony Tiganis
• Allele ID: MGI:5304815
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptpn1^tm2Bbk/Ptpn1^tm2Bbk Ptpn2^tm1.1Ttig/Ptpn2^tm1.1Ttig Tg(Nes-cre)1Kln/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL	MGI:5304839
cn2	Ptpn2^tm1.1Ttig/Ptpn2^tm1.1Ttig Tg(Nes-cre)1Kln/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:5304838

Genotype
MGI:5304839

cn1

• Allelic Composition: Ptpn1^tm2Bbk/Ptpn1^tm2Bbk; Ptpn2^tm1.1Ttig/Ptpn2^tm1.1Ttig; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal homeostasis ( J:179621 )

• whether fed standard chow or a high-fat diet, leptin-treated mice exhibit enhanced leptin sensitivity compared with wild-type mice

decreased circulating leptin level ( J:179621 )

• when fed standard chow

increased energy expenditure ( J:179621 )

• when fed standard chow

decreased susceptibility to diet-induced obesity ( J:179621 )

• when fed a high-fat diet

increased oxygen consumption ( J:179621 )

• when fed standard chow

abnormal respiratory quotient ( J:179621 )

• when fed standard chow, respiratory exchange ratio is decreased in the light cycle and increased in the dark cycle compared with wild-type mice

abnormal glucose homeostasis ( J:179621 )

• glucose homeostasis is improved in mice fed a high-fat diet compared to in wild-type mice

decreased circulating glucose level ( J:179621 )

• in fasted mice fed standard chow

increased insulin sensitivity ( J:179621 )

• when fed standard chow

growth/size/body

decreased body weight ( J:179621 )

• when fed standard chow

decreased body length ( J:179621 )

• when fed standard chow

decreased susceptibility to diet-induced obesity ( J:179621 )

• when fed a high-fat diet

behavior/neurological

abnormal eating behavior ( J:179621 )

• when fed standard chow

Genotype
MGI:5304838

cn2

• Allelic Composition: Ptpn2^tm1.1Ttig/Ptpn2^tm1.1Ttig; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

homeostasis/metabolism

abnormal homeostasis ( J:179621 )

• whether fed standard chow or a high-fat diet, leptin-treated mice exhibit enhanced leptin sensitivity with lower body weight and decreased food intake compared with wild-type mice

decreased circulating insulin-like growth factor I level ( J:179621 )

• in fed mice fed standard chow

decreased circulating leptin level ( J:179621 )

• in fed mice fed standard chow

decreased circulating growth hormone level ( J:179621 )

• in fed mice fed standard chow

increased energy expenditure ( J:179621 )

• in the dark phase when mice are fed standard chow

decreased susceptibility to diet-induced obesity ( J:179621 )

• when fed a high-fat diet

increased oxygen consumption ( J:179621 )

• in fed mice fed standard chow

abnormal glucose homeostasis ( J:179621 )

• glucose utilization is increased compared to in wild-type mice

decreased circulating glucose level ( J:179621 )

• in fasted mice whether fed standard chow or a high-fat diet

decreased circulating insulin level ( J:179621 )

• in fasted mice whether fed standard chow or a high-fat diet

increased insulin sensitivity ( J:179621 )

• in mice fed standard chow or a high-fat diet

increased adiponectin level ( J:179621 )

• in mice fed a high-fat diet, but not when mice are fed standard chow

skeleton

decreased bone mineral content ( J:179621 )

• in fed mice fed standard chow

decreased bone mineral density ( J:179621 )

• in fed mice fed standard chow

decreased trabecular bone volume ( J:179621 )

• in fed mice fed standard chow

decreased bone trabecula number ( J:179621 )

• in fed mice fed standard chow

growth/size/body

decreased body weight ( J:179621 )

• at 3 and 8 weeks of age in mice fed standard chow

• in leptin-treated mice

• in mice fed a high fat diet

decreased body length ( J:179621 )

• in fed mice fed standard chow

decreased susceptibility to diet-induced obesity ( J:179621 )

• when fed a high-fat diet

behavior/neurological

abnormal eating behavior ( J:179621 )

• at 8 to 10 weeks of age when fed standard chow

• in leptin-treated mice

decreased locomotor activity ( J:179621 )

• in fed mice fed standard chow

adipose tissue

increased total body fat amount ( J:179621 )

• relative adiposity is increased in male and female mice in mice fed standard chow

• in mice fed a high-fat diet

hematopoietic system

decreased bone marrow cell number ( J:179621 )

• in fed mice fed standard chow