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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Del(14Trim13-Rnaseh2b)6Rdf
deletion, Chr 14, Riccardo Dalla-Favera 6
MGI:5304666
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Del(14Trim13-Rnaseh2b)6Rdf/Del(14Trim13-Rnaseh2b)6Rdf involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 MGI:5305093
cn2
Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 MGI:5305095
cn3
Del(14Trim13-Rnaseh2b)6Rdf/+
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 MGI:5305096


Genotype
MGI:5305093
hm1
Allelic
Composition
Del(14Trim13-Rnaseh2b)6Rdf/Del(14Trim13-Rnaseh2b)6Rdf
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5305095
cn2
Allelic
Composition
Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (9 available); any Cd19 mutation (36 available)
Del(14Trim13-Rnaseh2b)6Rdf mutation (0 available); any Del(14Trim13-Rnaseh2b)6Rdf mutation (0 available)
Is(14)1Rdf mutation (0 available); any Is(14)1Rdf mutation (0 available)
Is(14)5Rdf mutation (1 available); any Is(14)5Rdf mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

neoplasm
• mice develop B cell clonal lymphoproliferations, chronic lymphocytic leukemia , small cell lymphomas, and CD5- non-Hodgkin lymphomas

immune system
• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220lo) with characteristics of chronic lymphocytic leukemia
• 42% of mice develop clonal lymphoproliferations
• IgM+CD5+B220lo

hematopoietic system
• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220lo) with characteristics of chronic lymphocytic leukemia
• 42% of mice develop clonal lymphoproliferations
• IgM+CD5+B220lo




Genotype
MGI:5305096
cn3
Allelic
Composition
Del(14Trim13-Rnaseh2b)6Rdf/+
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (9 available); any Cd19 mutation (36 available)
Del(14Trim13-Rnaseh2b)6Rdf mutation (0 available); any Del(14Trim13-Rnaseh2b)6Rdf mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 70% of mice die by 20 months

neoplasm
• mice develop B cell clonal lymphoproliferations, chronic lymphocytic leukemia , small cell lymphomas, and CD5- non-Hodgkin lymphomas

immune system
• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220lo) with characteristics of chronic lymphocytic leukemia
• 25% of mice develop clonal lymphoproliferations
• IgM+CD5+B220lo

hematopoietic system
• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220lo) with characteristics of chronic lymphocytic leukemia
• 25% of mice develop clonal lymphoproliferations
• IgM+CD5+B220lo





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory