All Phenotypes Maml3<tm1Mkit> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Maml3^tm1Mkit/Maml3^tm1Mkit	involves: 129P2/OlaHsd * C57BL/6	MGI:5301731
cx2	Maml1^tm1Mkit/Maml1^tm1Mkit Maml3^tm1Mkit/Maml3^tm1Mkit	B6.129P2-Maml3^tm1Mkit Maml1^tm1Mkit	MGI:5301733
cx3	Maml1^tm1Mkit/Maml1^tm1Mkit Maml3^tm1Mkit/Maml3^tm1Mkit	involves: 129P2/OlaHsd * C57BL/6	MGI:5301732

Allelic Composition	Maml3^tm1Mkit/Maml3^tm1Mkit
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maml3^tm1Mkit mutation (0 available); any Maml3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:178680 )

• viable and fertile with no gross abnormalities and normal splenocyte numbers

Allelic Composition	Maml1^tm1Mkit/Maml1^tm1Mkit Maml3^tm1Mkit/Maml3^tm1Mkit
Genetic Background	B6.129P2-Maml3^tm1Mkit Maml1^tm1Mkit

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maml1^tm1Mkit mutation (1 available); any Maml1 mutation (26 available)
Maml3^tm1Mkit mutation (0 available); any Maml3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:178680 )

• Background Sensitivity: lethality begins earlier compared to mice on a mixed 129P2/OlaHsd and C57BL/6 background

• underrepresented at E10.5 and absent by E11.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:178680 )

• survive up to E12.5

• Background Sensitivity: embryos survive longer compared to mice on an inbred C57BL/6 background

embryo

abnormal pharyngeal arch morphology ( J:178680 )

• at E9.5 to E10.5 embryos have a single branchial arch

decreased embryo size ( J:178680 )

• most embryos are smaller than littermate controls at E9.5 to E10.5

impaired somite development ( J:178680 )

• at E9.5

abnormal visceral yolk sac morphology ( J:178680 )

• at E9.5 to E10.5 the yolk sac has a rough texture and the vessels are barely visible

cardiovascular system

abnormal angiogenesis ( J:178680 )

• at E9.5 to E10.5 blood vessels are present but the structure is more primitive and less finely branched in the head region

abnormal heart looping ( J:178680 )

• poorly folded hearts are often seen in embryos at E9.5 to E10.5

enlarged pericardium ( J:178680 )

• often seen in embryos at E9.5 to E10.5

nervous system

abnormal neuron proliferation ( J:178680 )

• accelerated neurogenesis in the neural tube, forebrain and hindbrain

craniofacial