Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation
(11 available);
any
Cd19 mutation
(56 available)
Rc3h1tm1.1Mass mutation
(0 available);
any
Rc3h1 mutation
(42 available)
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immune system
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• due to expansion of B cells, regulatory T cells, CD4 and CD8 effector-like T cell, and eosinophils
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• mice exhibit an increase in CD4 and CD8 effector-like T cells in the spleen compared with control mice
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hematopoietic system
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• due to expansion of B cells, regulatory T cells, CD4 and CD8 effector-like T cell, and eosinophils
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• mice exhibit an increase in CD4 and CD8 effector-like T cells in the spleen compared with control mice
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growth/size/body
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• due to expansion of B cells, regulatory T cells, CD4 and CD8 effector-like T cell, and eosinophils
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation
(3 available);
any
Commd10 mutation
(24 available)
Rc3h1tm1.1Mass mutation
(0 available);
any
Rc3h1 mutation
(42 available)
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Increased spleen size in Rc3h1tm1.1Mass/Rc3h1tm1.1MassCommd10Tg(Vav1-icre)A2Kio/0 mice
immune system
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N |
• mice exhibit normal T cell development and autoimmunity
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• 1.5-fold but not as severe as in Rc3h1san homozygotes
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• immature and re-circulating B cells
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• increased numbers in the spleen
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• mice exhibit increased spontaneous germinal center formation compared with control mice
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hematopoietic system
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• 1.5-fold but not as severe as in Rc3h1san homozygotes
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• immature and re-circulating B cells
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• increased numbers in the spleen
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• mice exhibit increased spontaneous germinal center formation compared with control mice
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growth/size/body
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• 1.5-fold but not as severe as in Rc3h1san homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h1tm1.1Mass mutation
(0 available);
any
Rc3h1 mutation
(42 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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N |
• mice exhibit normal T cell development
• unlike in Rc3h1san homozygotes, mice do not exhibit increased follicular T cell differentiation or germinal center formation
• mice exhibit normal autoimmunity
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• with a short-lived effector-like phenotype
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• the number of monocytic macrophages is doubled compared to in control mice
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hematopoietic system
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• with a short-lived effector-like phenotype
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• the number of monocytic macrophages is doubled compared to in control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h1tm1.1Mass mutation
(0 available);
any
Rc3h1 mutation
(42 available)
Rc3h2tm1c(KOMP)Wtsi mutation
(0 available);
any
Rc3h2 mutation
(69 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• B220+ B cells are almost undetectable
• spleens often with reduced B cell counts
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• both frequency and absolute numbers are increased
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• significant decrease in total cell numbers for CD4+ cells
• significant decrease in naive CD4+ T cell numbers
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• significant decrease in naive CD8+ T cell numbers
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• splemomegaly at a young age
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• unorganized or absent follicular structures in the spleen
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• T cell areas of the spleen are unorganized, particularly those affecting CD8+ cells
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• severe immune dysregulation
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• increased activation of both CD4+ and CD8+ T cells
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hematopoietic system
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• increased activation of both CD4+ and CD8+ T cells
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• B220+ B cells are almost undetectable
• spleens often with reduced B cell counts
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• both frequency and absolute numbers are increased
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• significant decrease in total cell numbers for CD4+ cells
• significant decrease in naive CD4+ T cell numbers
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• significant decrease in naive CD8+ T cell numbers
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• splemomegaly at a young age
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• unorganized or absent follicular structures in the spleen
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• T cell areas of the spleen are unorganized, particularly those affecting CD8+ cells
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growth/size/body
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• splemomegaly at a young age
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cellular
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• increased activation of both CD4+ and CD8+ T cells
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Analysis Tools