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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Esr1tm3.1Ksk
targeted mutation 3.1, Kenneth S Korach
MGI:5301452
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Esr1tm3.1Ksk/Esr1tm3.1Ksk involves: 129S6/SvEvTac * C57BL/6 MGI:5301527


Genotype
MGI:5301527
hm1
Allelic
Composition		 Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm3.1Ksk mutation (1 available); any Esr1 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Uterine abnormalities in Esr1tm3.1Ksk/Esr1tm3.1Ksk mice

reproductive system
uterus cyst ( J:176459 )
• with hemorrhagic follicles

homeostasis/metabolism
abnormal response/metabolism to endogenous compounds ( J:176459 )
• uterine tissue in ovariectomized mice fails exhibit uterotropic responses to estradiol treatment compared to in similarly treated wild-type mice
• however, uterine tissue in ovariectomized mice uterotropic responses to ICI182780 and tamoxifen

integument
abnormal mammary gland development ( J:176459 )
• the mammary gland never develops beyond a rudimentary epithelial ductal tree unlike in wild-type mice

endocrine/exocrine glands
abnormal mammary gland development ( J:176459 )
• the mammary gland never develops beyond a rudimentary epithelial ductal tree unlike in wild-type mice

growth/size/body
uterus cyst ( J:176459 )
• with hemorrhagic follicles




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory