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Allele Symbol Allele Name Allele ID |
Cdkal1tm1.1Tomik targeted mutation 1.1, Kazuhito Tomizawa MGI:5301441 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Endoplasmic reticulum distention in Cdkal1tm1.2Tomik/Cdkal1tm1.2Tomik Tg(Ins2-cre)25Mgn/0 beta cells
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• the number of small islets is lower and the number of large islets is greater than in control mice
• however, the total number of islets is normal
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• beta cells exhibit endoplasmic reticulum stress unlike control cells
• beta cells exhibit decreased glucose-stimulated ATP synthesis compared with control cells
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• the first-phase of insulin secretion is impaired
• however, the second-phase is normal
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• in beta cells 15 minutes after glucose challenge
• following prostprandial stimulation
• in mice fed a high-fat diet
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• the first-phase of insulin secretion is impaired
• however, the second-phase is normal
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• in beta cells 15 minutes after glucose challenge
• following prostprandial stimulation
• in mice fed a high-fat diet
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• in fasting and nonfasting mice fed a high-fat diet
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• at 5 to 10 weeks of age
• in mice fed a high-fat diet
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 2 diabetes mellitus | DOID:9352 |
OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 |
J:178248 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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