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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ppargtm1.1(tTA)Jmgr
targeted mutation 1.1, Jonathan M Graff
MGI:5300919
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5581951
cn2
Ctnnb1tm2Kem/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5581952
cn3
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Tg(tetO-HIST1H2BJ/GFP)47Efu/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 MGI:5581950
cn4
Ctnnb1tm1Mmt/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:5581956


Genotype
MGI:5581951
cn1
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Ppargtm1.1(tTA)Jmgr mutation (1 available); any Pparg mutation (39 available)
Tg(tetO-cre)1Jaw mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• mice exhibit normal bone formation and osteoblast surface/numbers
• decreased proliferation of osteoclast precursors
• at 6 months
• more trabecular bone and bone surface at 6 months
• with reduced spacing at 6 months

hematopoietic system
• decreased proliferation of osteoclast precursors

immune system
• decreased proliferation of osteoclast precursors




Genotype
MGI:5581952
cn2
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Ppargtm1.1(tTA)Jmgr mutation (1 available); any Pparg mutation (39 available)
Tg(tetO-cre)1Jaw mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• doxycycline-treated mice exhibit normal numbers of osteoblasts, bone formation and bone mineral apposition rates
• in doxycycline-treated mice
• doxycycline-treated bone marrow cultures exhibit reduced osteoclast precursor proliferation compared with control cultures
• decreased bone surface in doxycycline-treated mice
• trabecular, cortical and total in doxycycline-treated mice
• with increased spacing in doxycycline-treated mice
• in doxycycline-treated mice
• in doxycycline-treated mice
• in doxycycline-treated mice
• in doxycycline-treated mice

hematopoietic system
• in doxycycline-treated mice
• doxycycline-treated bone marrow cultures exhibit reduced osteoclast precursor proliferation compared with control cultures

immune system
• in doxycycline-treated mice
• doxycycline-treated bone marrow cultures exhibit reduced osteoclast precursor proliferation compared with control cultures




Genotype
MGI:5581950
cn3
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Tg(tetO-HIST1H2BJ/GFP)47Efu/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Ppargtm1.1(tTA)Jmgr mutation (1 available); any Pparg mutation (39 available)
Tg(tetO-cre)1Jaw mutation (5 available)
Tg(tetO-HIST1H2BJ/GFP)47Efu mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

hematopoietic system
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

cellular
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

immune system
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice




Genotype
MGI:5581956
cn4
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Ppargtm1.1(tTA)Jmgr mutation (1 available); any Pparg mutation (39 available)
Tg(tetO-cre)1Jaw mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• doxycycline-treated mice exhibit normal bone formation and numbers of osteoblasts
• impaired in doxycycline-treated mice
• in doxycycline-treated mice
• as early as P15 in doxycycline-treated mice
• 27-fold from 10 months of age in doxycycline-treated mice
• in doxycycline-treated mice
• 4.6-fold increase in trabecular bone surface and a smaller bone surface to bone volume in doxycycline-treated mice
• trabecular, cortical and total volume as early as P15 in doxycycline-treated mice
• 3.6-fold with reduced trabecular separation in doxycycline-treated mice
• 8.5-fold in doxycycline-treated mice
• severe in doxycycline-treated mice
• in mice following adult onset activation with doxycycline
• in doxycycline-treated mice

hematopoietic system
• impaired in doxycycline-treated mice
• in doxycycline-treated mice
• at 4 months in doxycycline-treated mice
• at 10 months in doxycycline-treated mice
• in doxycycline-treated mice
• gradual in doxycycline-treated mice

cellular
• impaired in doxycycline-treated mice

immune system
• impaired in doxycycline-treated mice
• in doxycycline-treated mice
• gradual in doxycycline-treated mice





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory