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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptpmt1tm2.1Ckq
targeted mutation 2.1, Cheng-Kui Qu
MGI:5300822
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL MGI:5485994
cn2
Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL MGI:5485996
cn3
Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(Lck-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL MGI:5485995
cn4
Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL MGI:5485992
cn5
Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(VAV1-cre)1Graf/0
involves: 129S6/SvEvTac * C57BL/6J * SJL MGI:5485993


Genotype
MGI:5485994
cn1
Allelic
Composition
Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (9 available); any Lyz2 mutation (15 available)
Ptpmt1tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• macrophages exhibit decreased mitochondrial aerobic metabolism at basal levels and maximal reserve capacities compared with control cells

hematopoietic system
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors

immune system
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors
• macrophages exhibit normal growth and cell cycle




Genotype
MGI:5485996
cn2
Allelic
Composition
Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Ptpmt1tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors

immune system
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors




Genotype
MGI:5485995
cn3
Allelic
Composition
Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(Lck-cre)1Cwi/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpmt1tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (6 available)
Tg(Lck-cre)1Cwi mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors

immune system
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors




Genotype
MGI:5485992
cn4
Allelic
Composition
Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpmt1tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (6 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die within 2 to 3 weeks of pIpC treatment

hematopoietic system
N
• hematopoietic stem cells in pIpC-treated mice exhibit normal apoptosis rates
• decreased bone marrow myeloid and lymphoid progenitors in pIpC-treated mice
• severe in pIpC-treated mice
• decreased bone marrow myeloid and lymphoid progenitors in pIpC-treated mice
• in pIpC-treated mice
• increased hematopoietic stem cells and multipotent progenitors in the bone marrow of pIpC-treated mice
• hematopoietic stem cells (HCS) from pIpC-treated mice fail to differentiate in colony forming assays
• cell-autonomous defect in differentiation and blocked repopulating capabilities in HCS from pIpC-treated mice
• HSCs from pIpC-treated mice accumulate at the G1 phase and exhibit enhanced entry of quiescence




Genotype
MGI:5485993
cn5
Allelic
Composition
Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(VAV1-cre)1Graf/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpmt1tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (6 available)
Tg(VAV1-cre)1Graf mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• within 5 to 9 days of birth
• however, mice can be rescued by transplantation of wild-type bone marrow cells

hematopoietic system
• severe
• 30-fold; develops gradually

immune system

endocrine/exocrine glands





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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory