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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptpmt1tm2.1Ckq
targeted mutation 2.1, Cheng-Kui Qu
MGI:5300822
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL MGI:5485994
cn2
 		Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL MGI:5485996
cn3
 		Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(Lck-cre)1Cwi/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL MGI:5485995
cn4
 		Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(Mx1-cre)1Cgn/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL MGI:5485992
cn5
 		Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(VAV1-cre)1Graf/0 		involves: 129S6/SvEvTac * C57BL/6J * SJL MGI:5485993


Genotype
MGI:5485994
cn1
Allelic
Composition		 Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Ptpmt1tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal aerobic respiration ( J:194929 )
• macrophages exhibit decreased mitochondrial aerobic metabolism at basal levels and maximal reserve capacities compared with control cells

hematopoietic system
hematopoietic system phenotype ( J:194929 )
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors

immune system
immune system phenotype ( J:194929 )
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors
• macrophages exhibit normal growth and cell cycle




Genotype
MGI:5485996
cn2
Allelic
Composition		 Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Ptpmt1tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:194929 )
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors

immune system
immune system phenotype ( J:194929 )
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors




Genotype
MGI:5485995
cn3
Allelic
Composition		 Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpmt1tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (12 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:194929 )
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors

immune system
immune system phenotype ( J:194929 )
N
• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors




Genotype
MGI:5485992
cn4
Allelic
Composition		 Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpmt1tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (12 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:194929 )
• most mice die within 2 to 3 weeks of pIpC treatment

hematopoietic system
hematopoietic system phenotype ( J:194929 )
N
• hematopoietic stem cells in pIpC-treated mice exhibit normal apoptosis rates
decreased common myeloid progenitor cell number ( J:194929 )
• decreased bone marrow myeloid and lymphoid progenitors in pIpC-treated mice
anemia ( J:194929 )
• severe in pIpC-treated mice
abnormal common lymphocyte progenitor cell morphology ( J:194929 )
• decreased bone marrow myeloid and lymphoid progenitors in pIpC-treated mice
pancytopenia ( J:194929 )
• in pIpC-treated mice
increased hematopoietic stem cell number ( J:194929 )
• increased hematopoietic stem cells and multipotent progenitors in the bone marrow of pIpC-treated mice
abnormal hematopoietic stem cell physiology ( J:194929 )
• hematopoietic stem cells (HCS) from pIpC-treated mice fail to differentiate in colony forming assays
• cell-autonomous defect in differentiation and blocked repopulating capabilities in HCS from pIpC-treated mice
• HSCs from pIpC-treated mice accumulate at the G1 phase and exhibit enhanced entry of quiescence




Genotype
MGI:5485993
cn5
Allelic
Composition		 Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(VAV1-cre)1Graf/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpmt1tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (12 available)
Tg(VAV1-cre)1Graf mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:194929 )
• within 5 to 9 days of birth
• however, mice can be rescued by transplantation of wild-type bone marrow cells

hematopoietic system
anemia ( J:194929 )
• severe
increased hematopoietic stem cell number ( J:194929 )
• 30-fold; develops gradually

immune system

endocrine/exocrine glands




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04/16/2024
MGI 6.23 		The Jackson Laboratory