All Phenotypes Kitl<tm2.1Sjm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kitl^tm2.1Sjm
targeted mutation 2.1, Sean J Morrison
MGI:5300820

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kitl^tm1.1Sjm/Kitl^tm2.1Sjm Lepr^tm2(cre)Rck/Lepr⁺ Tg(Tek-cre)12Flv/0	involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL	MGI:5306357
cn2	Kitl^tm1.1Sjm/Kitl^tm2.1Sjm Lepr^tm2(cre)Rck/Lepr⁺	involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL	MGI:5306356
cn3	Kitl^tm2.1Sjm/Kitl^tm2.1Sjm Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0	involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL	MGI:5306350
cn4	Kitl^tm2.1Sjm/Kitl^tm2.2Sjm Tg(Tek-cre)12Flv/0	involves: BALB/cJ * C3H * C57BL/6 * C57BL/Ka * SJL	MGI:5306355
cn5	Kitl^tm2.1Sjm/Kitl^tm2.2Sjm Tg(Col1a1-cre)2Bek/0	involves: BALB/cJ * C57BL/6 * C57BL/Ka * CD-1 * SJL	MGI:5306352
cn6	Kitl^tm2.1Sjm/Kitl^tm2.2Sjm Tg(Nes-cre/ERT2)1Fsh/0	involves: BALB/cJ * C57BL/6 * C57BL/Ka * FVB/N * SJL	MGI:5306354
cn7	Kitl^tm2.1Sjm/Kitl^tm2.2Sjm Tg(Nes-cre)1Kln/0	involves: BALB/cJ * C57BL/6 * C57BL/Ka * SJL	MGI:5306353
cn8	Kitl^tm2.1Sjm/Kitl^tm2.2Sjm Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	involves: BALB/cJ * C57BL * CBA/Ca * SJL	MGI:5306351

Allelic Composition	Kitl^tm1.1Sjm/Kitl^tm2.1Sjm Lepr^tm2(cre)Rck/Lepr⁺ Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitl^tm1.1Sjm mutation (1 available); any Kitl mutation (92 available)
Kitl^tm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Lepr^tm2(cre)Rck mutation (1 available); any Lepr mutation (121 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

spleen hyperplasia ( J:180431 )

decreased bone marrow cell number ( J:180431 )

decreased hematopoietic cell number ( J:180431 )

• in the bone marrow

immune system

spleen hyperplasia ( J:180431 )

growth/size/body

spleen hyperplasia ( J:180431 )

Allelic Composition	Kitl^tm1.1Sjm/Kitl^tm2.1Sjm Lepr^tm2(cre)Rck/Lepr⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:180431 )

spleen hyperplasia ( J:180431 )

extramedullary hematopoiesis ( J:180431 )

• in the spleen

decreased hematopoietic cell number ( J:180431 )

• in the bone marrow and the spleen

• depletion in the bone marrow increases over time

immune system

enlarged spleen ( J:180431 )

spleen hyperplasia ( J:180431 )

growth/size/body

enlarged spleen ( J:180431 )

spleen hyperplasia ( J:180431 )

Allelic Composition	Kitl^tm2.1Sjm/Kitl^tm2.1Sjm Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitl^tm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mutation (6 available); any Ndor1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

anemia ( J:180431 )

• in tamoxifen-treated mice

decreased bone marrow cell number ( J:180431 )

• bone marrow cells from tamoxifen-treated mice used to repopulate irradiated mice exhibit reduced bone marrow-derived cell production (total, myeloid, T cell, and B cell)

decreased hematopoietic cell number ( J:180431 )

• in tamoxifen-treated mice

decreased erythrocyte cell number ( J:180431 )

• in tamoxifen-treated mice

abnormal bone marrow cell physiology ( J:180431 )

• bone marrow cells from tamoxifen-treated mice used to repopulate irradiated mice exhibit reduced bone marrow-derived cell production (total, myeloid, T cell, and B cell)

liver/biliary system

liver hypoplasia ( J:180431 )

• in tamoxifen-treated mice

Allelic Composition	Kitl^tm2.1Sjm/Kitl^tm2.2Sjm Tg(Tek-cre)12Flv/0
Genetic Background	involves: BALB/cJ * C3H * C57BL/6 * C57BL/Ka * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitl^tm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Kitl^tm2.2Sjm mutation (0 available); any Kitl mutation (92 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:180431 )

N	• mice exhibit normal blood cell counts and bone marrow and spleen cellularity

decreased hematopoietic cell number ( J:180431 )

• to a greater extent than in Kitl^tm2.2Sjm heterozygotes in the bone marrow

• 1.7-2.1-fold in the liver of newborn mice

• 2-fold in the bone marrow of 1 month old mice

• 2.7-5.2-fold in the bone marrow of 8 week old mice

abnormal bone marrow cell physiology ( J:180431 )

• bone marrow cells from tamoxifen-treated mice used to repopulate irradiated mice exhibit reduced bone marrow-derived cell production (total, myeloid, T cell, and B cell)

Allelic Composition	Kitl^tm2.1Sjm/Kitl^tm2.2Sjm Tg(Col1a1-cre)2Bek/0
Genetic Background	involves: BALB/cJ * C57BL/6 * C57BL/Ka * CD-1 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:180431 )

N	• exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity

decreased hematopoietic cell number ( J:180431 )

• 2-fold as in Kitl^tm2.2Sjm heterozygotes in the bone marrow

Allelic Composition	Kitl^tm2.1Sjm/Kitl^tm2.2Sjm Tg(Nes-cre/ERT2)1Fsh/0
Genetic Background	involves: BALB/cJ * C57BL/6 * C57BL/Ka * FVB/N * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:180431 )

N	• tamoxifen-treated mice exhibit normal hematopoiesis, hematopoietic stem cell frequency, and reconstitution capacity

Allelic Composition	Kitl^tm2.1Sjm/Kitl^tm2.2Sjm Tg(Nes-cre)1Kln/0
Genetic Background	involves: BALB/cJ * C57BL/6 * C57BL/Ka * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:180431 )

N	• mice exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity • unlike Kitl^tm2.2Sjm heterozygotes, mice exhibit normal numbers of hematopoietic stem cells in the spleen

Allelic Composition	Kitl^tm2.1Sjm/Kitl^tm2.2Sjm Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: BALB/cJ * C57BL * CBA/Ca * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Kitl^tm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Kitl^tm2.2Sjm mutation (0 available); any Kitl mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:180431 )

N	• exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity

decreased hematopoietic cell number ( J:180431 )

• 2-fold as in Kitl^tm2.2Sjm heterozygotes in the bone marrow

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