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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kitltm2.1Sjm
targeted mutation 2.1, Sean J Morrison
MGI:5300820
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Tg(Tek-cre)12Flv/0
involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL MGI:5306357
cn2
Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL MGI:5306356
cn3
Kitltm2.1Sjm/Kitltm2.1Sjm
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL MGI:5306350
cn4
Kitltm2.1Sjm/Kitltm2.2Sjm
Tg(Tek-cre)12Flv/0
involves: BALB/cJ * C3H * C57BL/6 * C57BL/Ka * SJL MGI:5306355
cn5
Kitltm2.1Sjm/Kitltm2.2Sjm
Tg(Col1a1-cre)2Bek/0
involves: BALB/cJ * C57BL/6 * C57BL/Ka * CD-1 * SJL MGI:5306352
cn6
Kitltm2.1Sjm/Kitltm2.2Sjm
Tg(Nes-cre/ERT2)1Fsh/0
involves: BALB/cJ * C57BL/6 * C57BL/Ka * FVB/N * SJL MGI:5306354
cn7
Kitltm2.1Sjm/Kitltm2.2Sjm
Tg(Nes-cre)1Kln/0
involves: BALB/cJ * C57BL/6 * C57BL/Ka * SJL MGI:5306353
cn8
Kitltm2.1Sjm/Kitltm2.2Sjm
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: BALB/cJ * C57BL * CBA/Ca * SJL MGI:5306351


Genotype
MGI:5306357
cn1
Allelic
Composition
Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1.1Sjm mutation (1 available); any Kitl mutation (84 available)
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (84 available)
Leprtm2(cre)Rck mutation (1 available); any Lepr mutation (90 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

hematopoietic system

immune system




Genotype
MGI:5306356
cn2
Allelic
Composition
Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1.1Sjm mutation (1 available); any Kitl mutation (84 available)
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (84 available)
Leprtm2(cre)Rck mutation (1 available); any Lepr mutation (90 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

hematopoietic system
• in the bone marrow and the spleen
• depletion in the bone marrow increases over time

immune system




Genotype
MGI:5306350
cn3
Allelic
Composition
Kitltm2.1Sjm/Kitltm2.1Sjm
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (84 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (5 available); any Ndor1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in tamoxifen-treated mice
• bone marrow cells from tamoxifen-treated mice used to repopulate irradiated mice exhibit reduced bone marrow-derived cell production (total, myeloid, T cell, and B cell)
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• bone marrow cells from tamoxifen-treated mice used to repopulate irradiated mice exhibit reduced bone marrow-derived cell production (total, myeloid, T cell, and B cell)

liver/biliary system
• in tamoxifen-treated mice




Genotype
MGI:5306355
cn4
Allelic
Composition
Kitltm2.1Sjm/Kitltm2.2Sjm
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: BALB/cJ * C3H * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (84 available)
Kitltm2.2Sjm mutation (0 available); any Kitl mutation (84 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal blood cell counts and bone marrow and spleen cellularity
• to a greater extent than in Kitltm2.2Sjm heterozygotes in the bone marrow
• 1.7-2.1-fold in the liver of newborn mice
• 2-fold in the bone marrow of 1 month old mice
• 2.7-5.2-fold in the bone marrow of 8 week old mice
• bone marrow cells from tamoxifen-treated mice used to repopulate irradiated mice exhibit reduced bone marrow-derived cell production (total, myeloid, T cell, and B cell)




Genotype
MGI:5306352
cn5
Allelic
Composition
Kitltm2.1Sjm/Kitltm2.2Sjm
Tg(Col1a1-cre)2Bek/0
Genetic
Background
involves: BALB/cJ * C57BL/6 * C57BL/Ka * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (84 available)
Kitltm2.2Sjm mutation (0 available); any Kitl mutation (84 available)
Tg(Col1a1-cre)2Bek mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity
• 2-fold as in Kitltm2.2Sjm heterozygotes in the bone marrow




Genotype
MGI:5306354
cn6
Allelic
Composition
Kitltm2.1Sjm/Kitltm2.2Sjm
Tg(Nes-cre/ERT2)1Fsh/0
Genetic
Background
involves: BALB/cJ * C57BL/6 * C57BL/Ka * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (84 available)
Kitltm2.2Sjm mutation (0 available); any Kitl mutation (84 available)
Tg(Nes-cre/ERT2)1Fsh mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• tamoxifen-treated mice exhibit normal hematopoiesis, hematopoietic stem cell frequency, and reconstitution capacity




Genotype
MGI:5306353
cn7
Allelic
Composition
Kitltm2.1Sjm/Kitltm2.2Sjm
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: BALB/cJ * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (84 available)
Kitltm2.2Sjm mutation (0 available); any Kitl mutation (84 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity
• unlike Kitltm2.2Sjm heterozygotes, mice exhibit normal numbers of hematopoietic stem cells in the spleen




Genotype
MGI:5306351
cn8
Allelic
Composition
Kitltm2.1Sjm/Kitltm2.2Sjm
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: BALB/cJ * C57BL * CBA/Ca * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (21 available)
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (84 available)
Kitltm2.2Sjm mutation (0 available); any Kitl mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity
• 2-fold as in Kitltm2.2Sjm heterozygotes in the bone marrow





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory