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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ggt1-Hif1a*)43Log
transgene insertion 43, Lorraine J Gudas
MGI:5298013
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Ggt1-Hif1a*)43Log/0 involves: C57BL/6 MGI:5298019


Genotype
MGI:5298019
tg1
Allelic
Composition
Tg(Ggt1-Hif1a*)43Log/0
Genetic
Background
involves: C57BL/6
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phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• dilated and filled with red blood cells near kidney cysts
• proximal tubule cells exhibit clear cells with moderate to marked swelling, cytoplasmic vacuolation, and prominent cell membranes covering 30% to 50% of the cortex indicative of clear cell renal cell carcinoma (ccRCC) unlike wild-type cells
• tubular cysts at 12 months
• however, not glomerular cysts are present

neoplasm
• proximal tubule cells exhibit clear cells with moderate to marked swelling, cytoplasmic vacuolation, and prominent cell membranes covering 30% to 50% of the cortex indicative of clear cell renal cell carcinoma (ccRCC) unlike wild-type cells

cardiovascular system
• dilated and filled with red blood cells near kidney cysts

Mouse Models of Human Disease
OMIM ID Ref(s)
Von Hippel-Lindau Syndrome; VHL 193300 J:177381





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory