renal/urinary system
|
• dilated and filled with red blood cells near kidney cysts
|
kidney cysts
(
J:177381
)
|
• tubular cysts at 12 months
• however, not glomerular cysts are present
|
tumorigenesis
|
• proximal tubule cells exhibit clear cells with moderate to marked swelling, cytoplasmic vacuolation, and prominent cell membranes covering 30% to 50% of the cortex indicative of clear cell renal cell carcinoma (ccRCC) unlike wild-type cells
|
cardiovascular system
|
• dilated and filled with red blood cells near kidney cysts
|
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Von Hippel-Lindau Syndrome; VHL | 193300 | J:177381 | |