Mouse Genome Informatics
tg1
    Tg(Ggt1-Hif1a*)43Log/0
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
renal/urinary system
• dilated and filled with red blood cells near kidney cysts
• tubular cysts at 12 months
• however, not glomerular cysts are present

tumorigenesis
• proximal tubule cells exhibit clear cells with moderate to marked swelling, cytoplasmic vacuolation, and prominent cell membranes covering 30% to 50% of the cortex indicative of clear cell renal cell carcinoma (ccRCC) unlike wild-type cells

cardiovascular system
• dilated and filled with red blood cells near kidney cysts

Mouse Models of Human Disease
OMIM IDRef(s)
Von Hippel-Lindau Syndrome; VHL 193300 J:177381