Mouse Genome Informatics
hm1
    Lrrk2tm1.2Npa/Lrrk2tm1.2Npa
involves: BALB/c * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
renal/urinary system
• in 22 month old female mice and 18 month old male mice
• dark kidneys around 5 months of age
• in male mice starting around 5 months of age
• tubular degeneration at 8 months of age with extracellular deposition of lipofuscin
• as early as 6 weeks after birth, mice exhibit localized microvacuolization consisting of accumulation of many small isometric vacuoles in the epithelial cells of the proximal tubules in the cortex and outer medulla
• microvacuoles become larger and more and more tubules are affected with age
• at 2 months, kidneys exhibit an increase in the number and size of secondary lysosomes in some proximal tubules
• at 6 months, proximal tubules contain enlarged and increased number of secondary lysosomes
• at 5 months of age

respiratory system
• microvascuolization in type II pneumocytes located within the alveolar-septal wall at 1.5 months of age
• from 2 and 6 months, type II pneumocytes exhibit increased number of lamellar bodies compared with wild-type cells

cardiovascular system
N
• mice exhibit normal systolic blood pressure and heart rate (J:176679)

homeostasis/metabolism
• in 22 month old female mice and 18 month old male mice

pigmentation
• in vacuolated epithelial cells of the proximal tubules in the cortex and outer medulla at 5 months
• extracellular deposition of lipofuscin at 8 months of age

nervous system
N
• mice exhibit no overt neuropathy in response to dopamine agonists/antagonists (J:176679)

behavior/neurological
N
• mice exhibit normal locomotor response to dopamine agonists/antagonists (J:176679)