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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lrrk2tm1.2Npa
targeted mutation 1.2, Novartis Pharma AG
MGI:5295370
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lrrk2tm1.2Npa/Lrrk2tm1.2Npa involves: BALB/c * C57BL/6J MGI:5295392


Genotype
MGI:5295392
hm1
Allelic
Composition
Lrrk2tm1.2Npa/Lrrk2tm1.2Npa
Genetic
Background
involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm1.2Npa mutation (0 available); any Lrrk2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• in 22 month old female mice and 18 month old male mice (J:176679)
• in 22 month old female mice and 18 month old male mice (J:176679)
• dark kidneys around 5 months of age (J:176679)
• dark kidneys around 5 months of age (J:176679)
• in male mice starting around 5 months of age (J:176679)
• in male mice starting around 5 months of age (J:176679)
• as early as 6 weeks after birth, mice exhibit localized microvacuolization consisting of accumulation of many small isometric vacuoles in the epithelial cells of the proximal tubules in the cortex and outer medulla (J:176679)
• microvacuoles become larger and more and more tubules are affected with age (J:176679)
• tubular degeneration at 8 months of age with extracellular deposition of lipofuscin (J:176679)
• at 2 months, kidneys exhibit an increase in the number and size of secondary lysosomes in some proximal tubules (J:176679)
• at 6 months, proximal tubules contain enlarged and increased number of secondary lysosomes (J:176679)
• as early as 6 weeks after birth, mice exhibit localized microvacuolization consisting of accumulation of many small isometric vacuoles in the epithelial cells of the proximal tubules in the cortex and outer medulla (J:176679)
• microvacuoles become larger and more and more tubules are affected with age (J:176679)
• tubular degeneration at 8 months of age with extracellular deposition of lipofuscin (J:176679)
• at 2 months, kidneys exhibit an increase in the number and size of secondary lysosomes in some proximal tubules (J:176679)
• at 6 months, proximal tubules contain enlarged and increased number of secondary lysosomes (J:176679)
• at 5 months of age (J:176679)
• at 5 months of age (J:176679)

respiratory system
• microvascuolization in type II pneumocytes located within the alveolar-septal wall at 1.5 months of age (J:176679)
• from 2 and 6 months, type II pneumocytes exhibit increased number of lamellar bodies compared with wild-type cells (J:176679)
• microvascuolization in type II pneumocytes located within the alveolar-septal wall at 1.5 months of age (J:176679)
• from 2 and 6 months, type II pneumocytes exhibit increased number of lamellar bodies compared with wild-type cells (J:176679)

cardiovascular system
N
• mice exhibit normal systolic blood pressure and heart rate (J:176679)
• mice exhibit normal systolic blood pressure and heart rate (J:176679)

homeostasis/metabolism
• in 22 month old female mice and 18 month old male mice (J:176679)
• in 22 month old female mice and 18 month old male mice (J:176679)

pigmentation
• in vacuolated epithelial cells of the proximal tubules in the cortex and outer medulla at 5 months (J:176679)
• extracellular deposition of lipofuscin at 8 months of age (J:176679)
• in vacuolated epithelial cells of the proximal tubules in the cortex and outer medulla at 5 months (J:176679)
• extracellular deposition of lipofuscin at 8 months of age (J:176679)

nervous system
N
• mice exhibit no overt neuropathy in response to dopamine agonists/antagonists (J:176679)
• mice exhibit no overt neuropathy in response to dopamine agonists/antagonists (J:176679)

behavior/neurological
N
• mice exhibit normal locomotor response to dopamine agonists/antagonists (J:176679)
• mice exhibit normal locomotor response to dopamine agonists/antagonists (J:176679)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory