Analysis Tools
cardiovascular system
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• some mutants show inflammation in the lungs, with congestion and fibrosis
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• collagen is localized around groups of small cardiomyocytes with perinuclear spaces, as a result of myofibril loss and myocytolysis
• atrial-specific granules, which contain the atrial natriuretic peptide, are more numerous in atrial cardiomyocytes than in wild-type mice
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• mitochondria are small in some cardiomyocytes and include defects such as breakage and deterioration of cristae and the presence of intramitochondrial lamellar bodies
• number of mitochondria in cardiomyocytes is reduced
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• at 4 months of age, ventricles exhibit myocyte disarray
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• atria show increased collagen deposition
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• at 4 months of age, atria are enlarged and rigid with areas of calcification
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• at 4 months of age, ventricles have a distorted shape
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• evidence of cardiac hypertrophy at 4 months of age
• heart mass progressively increases from about 4 weeks of age in males and about 8 weeks of age in females
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• ventricles exhibit progressive interstitial fibrosis, first detected at 2 weeks of age
• at 4 weeks of age, males and females have equal amounts of fibrosis but by 8 weeks of age, male have more fibrosis than females
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• mutants exhibit decreased ejection fraction
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• cardiomyopathy characterized by ventricular wall thinning and increase in size of ventricular cavity
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• 24% of males and 20% of females exhibit heart failure by 20 weeks of age
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cellular
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• mitochondria are small in some cardiomyocytes and include defects such as breakage and deterioration of cristae and the presence of intramitochondrial lamellar bodies
• number of mitochondria in cardiomyocytes is reduced
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• ventricles exhibit progressive interstitial fibrosis, first detected at 2 weeks of age
• at 4 weeks of age, males and females have equal amounts of fibrosis but by 8 weeks of age, male have more fibrosis than females
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• number of mitochondria in cardiomyocytes is reduced
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• oxygen consumption and membrane potential are reduced in mitochondria, indicating compromised electron transport chain activity
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homeostasis/metabolism
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• 75% of males and 30% of females exhibit thrombus in one or both atria from 6 weeks of age
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• pleural effusion is seen in some mutants
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immune system
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• some mutants show inflammation in the lungs
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mortality/aging
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• 24% of males and 20% of females die from heart failure by 20 weeks of age
• more males than females die prior to 8 weeks
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• females fail to survive after parturition
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muscle
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• collagen is localized around groups of small cardiomyocytes with perinuclear spaces, as a result of myofibril loss and myocytolysis
• atrial-specific granules, which contain the atrial natriuretic peptide, are more numerous in atrial cardiomyocytes than in wild-type mice
|
|
• mitochondria are small in some cardiomyocytes and include defects such as breakage and deterioration of cristae and the presence of intramitochondrial lamellar bodies
• number of mitochondria in cardiomyocytes is reduced
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• at 4 months of age, ventricles exhibit myocyte disarray
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• mutants exhibit decreased ejection fraction
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• cardiomyopathy characterized by ventricular wall thinning and increase in size of ventricular cavity
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respiratory system
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• some mutants show inflammation in the lungs, with congestion and fibrosis
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• pleural effusion is seen in some mutants
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• some mutants show inflammation in the lungs
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• some mutants show inflammation in the lungs, with congestion and fibrosis
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growth/size/body
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• evidence of cardiac hypertrophy at 4 months of age
• heart mass progressively increases from about 4 weeks of age in males and about 8 weeks of age in females
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cardiomyopathy | DOID:0050700 | J:175885 | ||
