All Phenotypes Hsp90aa1<tm1.1Udon> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hsp90aa1^tm1.1Udon
targeted mutation 1.1, Heiichiro Udono
MGI:5294812

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsp90aa1^tm1.1Udon/Hsp90aa1^tm1.1Udon	involves: C57BL/6	MGI:5294831
hm2	Hsp90aa1^tm1.1Udon/Hsp90aa1^tm1.1Udon	involves: C57BL/6 * FVB	MGI:5441570

Allelic Composition	Hsp90aa1^tm1.1Udon/Hsp90aa1^tm1.1Udon
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsp90aa1^tm1.1Udon mutation (0 available); any Hsp90aa1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell physiology ( J:177143 )

• bone marrow-derived dentritic cells exhibit impaired translocation of internalized antigens into the cytosol compared with wild-type cells

• however, phagocytosis is normal

abnormal dendritic cell antigen presentation ( J:177143 )

• cross-presentation and, to a less extent, direct presentation are down-regulated when bone marrow-derived dendritic cells after a pulse with ovalbumin or transfection with an ovalbumin expressing plasmid compared with similarly treated wild-type cells

decreased interferon-gamma secretion ( J:177143 )

• from bone marrow-derived dendritic cells pulsed with cell-associated ovalbumin (UV irradiated Tap1^tm1Arp cells osmotically loaded with ovalbumin) subsequently incubated with Tg(TcraTcrb)1100Mjb CD8+ T cells

• from splenic CD8+ T cells of mice immunized with Tap1^tm1Arp splenic cells osmotically loaded with ovalbumin after stimulation with ovalbumin 257-264 epitope pulsed DC2.4 cells

Allelic Composition	Hsp90aa1^tm1.1Udon/Hsp90aa1^tm1.1Udon
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsp90aa1^tm1.1Udon mutation (0 available); any Hsp90aa1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:187954 )

• fewer offspring are produced when heterozygotes are bred

reproductive system

reproductive system phenotype ( J:187954 )

N	• mice exhibit normal Sertoli and Leydig cells

azoospermia ( J:187954 )

• no spermatozoa in the caudal epididymis at 8 to 10 weeks

increased male germ cell apoptosis ( J:187954 )

• progressive with age

small testis ( J:187954 )

• nearly one third of normal size

small scrotum ( J:187954 )

• at 8 weeks

male infertility ( J:187954 )