Analysis Tools
renal/urinary system
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• mice develop hydronephrosis following doxycycline induction
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neoplasm
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Allele Symbol Allele Name Allele ID |
Col1a1tm2(tetO-LIN28B)Gqda targeted mutation 2, George Q Daley MGI:5294612 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop hydronephrosis following doxycycline induction
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• small kidney in mice induced with doxycycline from E14.5 until the end of the experiment
• however, cap mesenchyme differentiates normally in doxycycline induced mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice develop kidney tumors within the first 2 weeks of life following doxycycline (Dox) induction during embryonic development at E0, E14.5 or E18.5
• tumors resemble Wilms tumor
• mice treated with doxycycline at P10 do not develop tumors
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• mice treated with doxycycline at P10 develop cystic kidneys
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• all mice develop kidney tumors within the first 2 weeks of life following doxycycline (Dox) induction during embryonic development at E0, E14.5 or E18.5
• tumors resemble Wilms tumor
• mice treated with doxycycline at P10 do not develop tumors
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• doxycycline induced mice exhibit persistent proliferation of cap mesenchyme cells in adults
• however, cap mesenchyme cells within tumors retain a differentiation capacity that recapitulates normal kidney development
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• timing of kidney development is prolonged in doxycycline induced mice, with sustaining proliferation of the cap mesenchyme cells into adulthood
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• mice treated with doxycycline at P10 develop cystic kidneys
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| nephroblastoma | DOID:2154 |
OMIM:194070 |
J:211179 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop cystic kidneys when transgene expression is induced with doxycycline early in embryonic development or in adult mice
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• mice develop cystic kidneys when transgene expression is induced with doxycycline early in embryonic development or in adult mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no kidney pathology is seen in mice induced with doxycycline
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following doxycycline treatment mice gain less weight when fed a high fat diet compared to wild-type mice
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• following doxycycline treatment mice gain less weight when fed a high fat diet compared to wild-type mice
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• following doxycycline treatment average fasting glucose is less than 50 mg/dL
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• following doxycycline treatment on a normal or high fat diet
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• following doxycycline treatment
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• following doxycycline treatment responses in a glucose tolerance test are similar to controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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