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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trib2Tg(Thy1-Trh/APP*)2.1Ingm
transgene insertion 2.1, Ingenium Pharmaceuticals
MGI:5294354
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm involves: C57BL/6 * DBA/1 MGI:5294357
cx2
Qpcttm1.2Tbay/Qpcttm1.2Tbay
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm
involves: 129S2/SvPas * C57BL/6J MGI:5294364
cx3
Qpctlm1Ingm/Qpctlm1Ingm
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm
involves: C3HeB/FeJ MGI:5294365
cx4
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+
Tg(Thy1-APP*)2.2Ingm/0
involves: C57BL/6 * DBA/1 MGI:5294359


Genotype
MGI:5294357
hm1
Allelic
Composition
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm
Genetic
Background
involves: C57BL/6 * DBA/1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trib2Tg(Thy1-Trh/APP*)2.1Ingm mutation (0 available); any Trib2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• between 5 and 7 months of age often due to feeding difficulties

nervous system
• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age
• neuronal loss is seen at 3 months of age in the CA1 pyramidal cell layer
• loss of more than 40% of neurons in the rostral hippocampal CA1 region
• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age
• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age
• at 2 and 3 months of age
• reduced at 5 months of age
• progressive age dependent astrocytosis beginning at 2 months of age
• at 5 months of age
• dramatic loss detectable at P28

behavior/neurological
• onset of behavioral phenotypes at 4 weeks of age
• progressive decline in home cage free drinking behavior with age
• progressive decline in home cage free feeding behavior with age
• display cramping or tremors when lifted by the tail
• at 3 months of age
• performance on a rotarod is less than 20% that of wild-type controls
• abnormal posture and rigor at 3 months of age
• progressive decline with age

growth/size/body
• about 30% lower compared to wild-type controls at 4.5 months of age
• detectable at 4 weeks of age

hematopoietic system
• at 2 and 3 months of age
• reduced at 5 months of age

immune system
• at 2 and 3 months of age
• reduced at 5 months of age

homeostasis/metabolism
• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:176575




Genotype
MGI:5294364
cx2
Allelic
Composition
Qpcttm1.2Tbay/Qpcttm1.2Tbay
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qpcttm1.2Tbay mutation (0 available); any Qpct mutation (7 available)
Trib2Tg(Thy1-Trh/APP*)2.1Ingm mutation (0 available); any Trib2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the pyroglutamate amyloid beta load is reduced compared to transgenic mice wild-type for Qpct

homeostasis/metabolism
• the pyroglutamate amyloid beta load is reduced compared to transgenic mice wild-type for Qpct




Genotype
MGI:5294365
cx3
Allelic
Composition
Qpctlm1Ingm/Qpctlm1Ingm
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm
Genetic
Background
involves: C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qpctlm1Ingm mutation (0 available); any Qpctl mutation (2 available)
Trib2Tg(Thy1-Trh/APP*)2.1Ingm mutation (0 available); any Trib2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the pyroglutamate amyloid beta load is similar to transgenic mice wild-type for Qpctl

homeostasis/metabolism
• the pyroglutamate amyloid beta load is similar to transgenic mice wild-type for Qpctl




Genotype
MGI:5294359
cx4
Allelic
Composition
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+
Tg(Thy1-APP*)2.2Ingm/0
Genetic
Background
involves: C57BL/6 * DBA/1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APP*)2.2Ingm mutation (0 available)
Trib2Tg(Thy1-Trh/APP*)2.1Ingm mutation (0 available); any Trib2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
• neurodegeneration in the CA1 pyramidal cell layer
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

behavior/neurological
• delayed
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
• display cramping or tremors when lifted by the tail
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

growth/size/body
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

hematopoietic system
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

immune system
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:176575





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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory