Mouse Genome Informatics
cx1
     Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+
Tg(Thy1-APP*)2.2Ingm/0
involves: C57BL/6 * DBA/1
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
nervous system
microgliosis ( J:176575 )
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
hippocampus pyramidal cell degeneration ( J:176575 )
• neurodegeneration in the CA1 pyramidal cell layer
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
astrocytosis ( J:176575 )
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

behavior/neurological
impaired righting response ( J:176575 )
• delayed
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
limb grasping ( J:176575 )
• display cramping or tremors when lifted by the tail
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

growth/size
slow postnatal weight gain ( J:176575 )
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

hematopoietic system
microgliosis ( J:176575 )
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

immune system
microgliosis ( J:176575 )
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

Mouse Models of Human Disease
 OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:176575