Mouse Genome Informatics
cx1
    Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+
Tg(Thy1-APP*)2.2Ingm/0

involves: C57BL/6 * DBA/1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
• neurodegeneration in the CA1 pyramidal cell layer
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

behavior/neurological
• delayed
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
• display cramping or tremors when lifted by the tail
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

growth/size
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

hematopoietic system
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

immune system
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:176575