Phenotypes associated with this allele

• Allele Symbol: Hcn1^tm1.1Lex
• Allele Name: targeted mutation 1.1, Lexicon Genetics
• Allele ID: MGI:5293229
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hcn1^tm1.1Lex/Hcn1^tm1.1Lex	129S/SvEvBrd-Hcn1^tm1.1Lex	MGI:5293232

Genotype
MGI:5293232

hm1

• Allelic Composition: Hcn1^tm1.1Lex/Hcn1^tm1.1Lex
• Genetic Background: 129S/SvEvBrd-Hcn1^tm1.1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:176560 )

• 9 of 12 dorsal root ganglion neurons fail to exhibit hyperpolarization-activated currents unlike wild-type neurons

• neurons lack initial amplitudes of the fast activation values unlike wild-type neurons

behavior/neurological

abnormal pain threshold ( J:176560 )

• following partial sciatic nerve ligation, mice exhibit reduced cold allodynia compared with similarly treated wild-type mice