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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Angptl8tm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:5292942
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Angptl8tm1(KOMP)Vlcg/Angptl8tm1(KOMP)Vlcg involves: C57BL/6NTac MGI:5616349
ht2
Angptl8tm1(KOMP)Vlcg/Angptl8+ involves: C57BL/6NTac MGI:5616350


Genotype
MGI:5616349
hm1
Allelic
Composition
Angptl8tm1(KOMP)Vlcg/Angptl8tm1(KOMP)Vlcg
Genetic
Background
involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl8tm1(KOMP)Vlcg mutation (0 available); any Angptl8 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice show no differences in oxygen consumption, respiratory exchange ratio, food and water intake, physical activity, core body temperature or fecal fat excretion
• plasma glucose and insulin levels in the fasted and fed states are not altered in mutants and mice fed a high-fat diet for 11 weeks exhibit a similar increase of insulin to glucose ratio and glucose tolerance like wild-type mice
• 70% reduction in plasma triglyceride levels when fed a chow diet ad libitum
• plasma triglyceride levels are reduced in fed but not in fasted mutants
• 40% reduction in plasma nonesterified fatty acid levels when fed a chow diet ad libitum
• however, mice on a 12 hour fasting/12 hour feeding cycle for 3 days, do not exhibit a difference in plasma noesterified fatty acid levels
• chow-fed mutants show an increase in heparin-releasable lipoprotein lipase activity
• reduction in VLDL triglyceride secretion
• in oral fat tolerance tests, mutants show attenuated excursion of plasma triglyceride levels following an oil gavage, indicating accelerated clearance of dietary fat
• the feeding-induced increase in VLDL-triglyceride uptake by adipose tissue that is seen in wild-type mice is abolished in mutants
• however, hepatic steatosis is not seen

adipose tissue
• small decrease in body fat content is seen by 12 weeks of age
• decreased body weight is entirely attributed to a reduced accumulation of adipose tissue
• lean mass is normal
• small decrease in percent body fat is seen by 12 weeks of age

growth/size/body
• after 12 weeks of age
• after 12 weeks of age, mutants fail to gain weight at the same rate as wild-type mice




Genotype
MGI:5616350
ht2
Allelic
Composition
Angptl8tm1(KOMP)Vlcg/Angptl8+
Genetic
Background
involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl8tm1(KOMP)Vlcg mutation (0 available); any Angptl8 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice show plasma triglyceride levels intermediate between those of wild-type and homozygous mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory