Phenotypes associated with this allele

• Allele Symbol: Nfat5^tm1Skc
• Allele Name: targeted mutation 1, Sookja K Chung
• Allele ID: MGI:5287396
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfat5^tm1Skc/Nfat5^tm1Skc	involves: 129S7/SvEvBrd * C57BL/6	MGI:5287397

Genotype
MGI:5287397

hm1

• Allelic Composition: Nfat5^tm1Skc/Nfat5^tm1Skc
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Peripheral edema in E14.5 Nfat5^tm1Skc/Nfat5^tm1Skc embryos

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:175527 )

• reduced numbers found from E17.5 onwards

prenatal lethality, complete penetrance ( J:175527 )

• heterozygous matings do not yield homozygous offspring

cardiovascular system

abnormal myocardial trabeculae morphology ( J:175527 )

• loosely packed cells

abnormal myocardium compact layer morphology ( J:175527 )

• loosely packed cells

thin ventricular wall ( J:175527 )

• at E14.5

abnormal cardiovascular system physiology ( J:175527 )

• decrease in the number of beats per minute, irregular calcium oscillations, and increased calcium release in isolated, synchronized cardiomyocytes from E14.5 mice

• increase in cleaved caspase 3 positive cells in the compact zone, trabeculae and epicardium

• however, the number of BCL2 and BAX positive cells are not increased

abnormal fetal cardiomyocyte proliferation ( J:175527 )

• decreased at E14.5

hematopoietic system

anemia ( J:175527 )

• appear anemic at E14.5

homeostasis/metabolism

edema ( J:175527 )

• at E14.5

muscle

abnormal myocardial trabeculae morphology ( J:175527 )

• loosely packed cells

abnormal myocardium compact layer morphology ( J:175527 )

• loosely packed cells

abnormal fetal cardiomyocyte proliferation ( J:175527 )

• decreased at E14.5

cellular

abnormal fetal cardiomyocyte proliferation ( J:175527 )

• decreased at E14.5