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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo
transgene insertion C63, David R Borchelt
MGI:5286114
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo/0 Not Specified MGI:5286128


Genotype
MGI:5286128
tg1
Allelic
Composition
Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
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phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die by 8 months of age when they are unable to acquire food or water
• average endpoint is 247 days

nervous system
• by half at end-stage
• contains large inclusions
• profound hippocampal degeneration in the CA1 and CA2 regions with partial degeneration in the CA3 region
• contain Htt+ cytoplasmic inclusions

behavior/neurological
• mice exhibit dyskinesia with ataxia-like movement compared with control mice
• beginning at 4 months and worsening to end-stage by 8 months of age
• at 4 months
• in mice displaying dyskinesia on a rotarod
• at 3 months, mice exhibit a moderate rotarod deficit that progresses to severe by 6 months of age compared with control mice
• aged mice exhibit a 10- to 50-fold deficit in latency to fall on a rotarod compared with control mice

growth/size/body
• by one third at end-stage

homeostasis/metabolism
• at end-stage

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:173756





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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory