All Phenotypes Myh9<tm7.1Rsad> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myh9^tm7.1Rsad
targeted mutation 7.1, Robert S Adelstein
MGI:5285643

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh9^tm7.1Rsad/Myh9^tm7.1Rsad	involves: BALB/cJ	MGI:5499740
ht2	Myh9^tm7.1Rsad/Myh9⁺	involves: BALB/cJ	MGI:5499738

Allelic Composition	Myh9^tm7.1Rsad/Myh9^tm7.1Rsad
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh9^tm7.1Rsad mutation (0 available); any Myh9 mutation (218 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal megakaryocyte morphology ( J:175367 )

• with neutrophil inclusions in the bone marrow

increased megakaryocyte cell number ( J:175367 )

• in the bone marrow and spleen

abnormal neutrophil morphology ( J:175367 )

• contain Myh9 aggregates

abnormal platelet morphology ( J:175367 )

• increased diameter

thrombocytopenia ( J:175367 )

• macrothrombocytopenia

homeostasis/metabolism

increased bleeding time ( J:175367 )

albuminuria ( J:175367 )

immune system

abnormal neutrophil morphology ( J:175367 )

• contain Myh9 aggregates

renal/urinary system

albuminuria ( J:175367 )

glomerulosclerosis ( J:175367 )

• focal segmental glomerulosclerosis and focal global glomerulosclerosis beginning at 4 months

vision/eye

cataract ( J:175367 )

• bilateral in some mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
MYH-9 related disease		DOID:0060651	OMIM:155100	J:175367

Allelic Composition	Myh9^tm7.1Rsad/Myh9⁺
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh9^tm7.1Rsad mutation (0 available); any Myh9 mutation (218 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased megakaryocyte cell number ( J:175367 )

• in the bone marrow and spleen

abnormal neutrophil morphology ( J:175367 )

• contain Myh9 aggregates

abnormal platelet morphology ( J:175367 )

• increased diameter

thrombocytopenia ( J:175367 )

• macrothrombocytopenia

homeostasis/metabolism

increased bleeding time ( J:175367 )

albuminuria ( J:175367 )

immune system

abnormal neutrophil morphology ( J:175367 )

• contain Myh9 aggregates

renal/urinary system

albuminuria ( J:175367 )

glomerulosclerosis ( J:175367 )

• focal segmental glomerulosclerosis and focal global glomerulosclerosis beginning at 4 months

vision/eye

cataract ( J:175367 )

• bilateral in some mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
MYH-9 related disease		DOID:0060651	OMIM:155100	J:175367

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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