Mouse Genome Informatics
cn1
    H2-Ab1tm1Koni/H2-Ab1tm1.1Koni
Tg(Tek-cre)12Flv/0

involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• T regulatory cells exhibit division in response to IL2 (J:131774)
• CD4+CD25+ exhibit effective suppressive activity (J:131774)
• 1.5- to 2-fold in CD4+CD8- but not CD8-CD4+CD25+
• mice exhibit a reduced number of preactivated CD4 T cells and CD4+CD25+ cells compared with wild-type mice
• CD4+CD25+ fopx3high T regulatory cells exhibit reduced CD25 expression compared with control cells
• in splenic hemopoietic cells (B cells, CD8a- dendritic cells, and CD8a+ dendritic cells) and Langerhans cells

hematopoietic system
• 1.5- to 2-fold in CD4+CD8- but not CD8-CD4+CD25+
• mice exhibit a reduced number of preactivated CD4 T cells and CD4+CD25+ cells compared with wild-type mice
• CD4+CD25+ fopx3high T regulatory cells exhibit reduced CD25 expression compared with control cells
• in splenic hemopoietic cells (B cells, CD8a- dendritic cells, and CD8a+ dendritic cells) and Langerhans cells


Mouse Genome Informatics
cx2
    H2-Ab1tm1.1Koni/H2-Ab1tm1.1Koni
Tg(Tek-cre)12Flv/0

involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• fewer than expected mice are produced