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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxj1tm1.2Ctk
targeted mutation 1.2, Chay T Kuo
MGI:5285547
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Foxj1tm1.1Ctk/Foxj1tm1.2Ctk
Tg(FOXJ1-EGFP)85Leo/0
Tg(Nes-cre)1Kln/0 		involves: C3H * C57BL/6 * C57BL/6J * SJL MGI:5285556
cn2
 		Foxj1tm1.1Ctk/Foxj1tm1.2Ctk
Tg(FOXJ1-cre/ERT2)1Blh/0 		involves: C57BL/6 * DBA MGI:5285554
cn3
 		Foxj1tm1.1Ctk/Foxj1tm1.2Ctk
Tg(Nes-cre)1Kln/0 		involves: C57BL/6 * SJL MGI:5285555


Genotype
MGI:5285556
cn1
Allelic
Composition		 Foxj1tm1.1Ctk/Foxj1tm1.2Ctk
Tg(FOXJ1-EGFP)85Leo/0
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C3H * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxj1tm1.1Ctk mutation (0 available); any Foxj1 mutation (20 available)
Foxj1tm1.2Ctk mutation (0 available); any Foxj1 mutation (20 available)
Tg(FOXJ1-EGFP)85Leo mutation (1 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:174694 )
• postnatal radial glial progenitors fail to organize into clusters unlike in wild-type mice
• neural stem cells fail to form ependymal niches unlike in wild-type mice
• however, RC2+ radial glial cells transition into neural stem cells

cellular
abnormal neuron differentiation ( J:174694 )
• postnatal radial glial progenitors fail to organize into clusters unlike in wild-type mice
• neural stem cells fail to form ependymal niches unlike in wild-type mice
• however, RC2+ radial glial cells transition into neural stem cells




Genotype
MGI:5285554
cn2
Allelic
Composition		 Foxj1tm1.1Ctk/Foxj1tm1.2Ctk
Tg(FOXJ1-cre/ERT2)1Blh/0
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxj1tm1.1Ctk mutation (0 available); any Foxj1 mutation (20 available)
Foxj1tm1.2Ctk mutation (0 available); any Foxj1 mutation (20 available)
Tg(FOXJ1-cre/ERT2)1Blh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:174694 )
• mice injected with tamoxifen at P14 exhibit defective coverage of the ventricular wall with neuroblast chains compared to in control mice
abnormal rostral migratory stream morphology ( J:174694 )
• at P28, mice injected with tamoxifen at P14 exhibit decreased rostral migratory stream cellularity/size compared with control mice
hydrocephaly ( J:174694 )
• in some mice injected with tamoxifen at P14

cellular
abnormal neuron differentiation ( J:174694 )
• mice injected with tamoxifen at P14 exhibit defective coverage of the ventricular wall with neuroblast chains compared to in control mice




Genotype
MGI:5285555
cn3
Allelic
Composition		 Foxj1tm1.1Ctk/Foxj1tm1.2Ctk
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxj1tm1.1Ctk mutation (0 available); any Foxj1 mutation (20 available)
Foxj1tm1.2Ctk mutation (0 available); any Foxj1 mutation (20 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain morphology ( J:174694 )
• after P7, maturing ependymal cells lack multicilia unlike in wild-type mice
hydrocephaly ( J:174694 )
• after P7




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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory