Analysis Tools
mortality/aging
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• some die between E13.5 and E18.5
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• some die between E11.5 and E13.5
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• at E18.5 only 7% of mice are homozygous rather than the expected 25%
• death occurs between E11.5 and E18.5
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reproductive system
| N |
• males are fertile
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• at P5 ovaries contained less than 20% as many oocytes as wild-type ovaries
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• at E13.5 and P5
• however, gonocyte proliferation is seen at P5 and P10 in males
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• at E11.5, most males and females have less than 5% as many germ cells as found in wild-type littermate controls in the genital ridge
• at E13.5 the number of MVH+ germ cells is reduced in males and females
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• many mislocalized PGCs (located near the hindlimb buds and the base of the tail) are seen at E9.5
• ectopic PGCs are detected as early as E8.5 and as late as E11.5
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• at 5-8 weeks of age a small number of follicles are occasionally seen
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• ovaries display very few primordial follicles at P5 and P10
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• ovaries of females older than 10 weeks of age lack follicular structures
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small ovary
(
J:175228
)
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• ovary volume is less than 20% that of wild-type controls in adult females
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• empty tubules are seen alongside tubules filled with germ cells at various stages of spermatogenesis
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embryo
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• before E10.5 about 16% of embryos are located outside the yolk sac
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• in embryos with developmental delay
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• about 40% of embryos display general developmental delay by E8.5
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• in embryos with developmental delay
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• embryos with developmental delay have a reduced number of somites
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• in embryos with developmental delay
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nervous system
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• in embryos with developmental delay
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growth/size/body
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• about 40% of embryos display general developmental delay by E8.5
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endocrine/exocrine glands
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• at 5-8 weeks of age a small number of follicles are occasionally seen
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• ovaries display very few primordial follicles at P5 and P10
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• ovaries of females older than 10 weeks of age lack follicular structures
|
small ovary
(
J:175228
)
|
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• ovary volume is less than 20% that of wild-type controls in adult females
|
|
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• empty tubules are seen alongside tubules filled with germ cells at various stages of spermatogenesis
|
cellular
|
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• at P5 ovaries contained less than 20% as many oocytes as wild-type ovaries
|
|
|
• at E13.5 and P5
• however, gonocyte proliferation is seen at P5 and P10 in males
|
|
• at E11.5, most males and females have less than 5% as many germ cells as found in wild-type littermate controls in the genital ridge
• at E13.5 the number of MVH+ germ cells is reduced in males and females
|
|
• many mislocalized PGCs (located near the hindlimb buds and the base of the tail) are seen at E9.5
• ectopic PGCs are detected as early as E8.5 and as late as E11.5
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