Mouse Genome Informatics
hm1
    Dnaic1b2b284Clo/Dnaic1b2b284Clo
C57BL/6J-Dnaic1b2b284Clo
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype

Dextrocardia with parallel outflow tracts suggestive of DORV (confirmed by EFIC imaging).

cardiovascular system
• a spectrum of complex congenital heart disease is seen in conjunction with heterotaxy
• hypoplastic transverse arch
• multiple ventricular septal defects

growth/size/body
• heterotaxy where the left-right positioning of organs may be randomized (J:216862)

respiratory system
• airway cilia are missing the outer dynein arms

cellular
• cilia in tracheal epithelia show missing out dynein arm defect
• airway cilia are missing the outer dynein arms
• mice exhibit immotile/slow/dyskinetic cilia with little or no net fluid flow

mortality/aging
• mice that survive postnatally usually die from hydrocephalus by 5-10 days after birth

nervous system
• mice that survive postnatally usually die from hydrocephalus by 5-10 days after birth

Mouse Models of Human Disease
OMIM IDRef(s)
Ciliary Dyskinesia, Primary, 1; CILD1 244400 J:175213