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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dnaic1b2b284Clo
Bench to Bassinet Program (B2B/CVDC), mutation 284 Cecilia Lo
MGI:5285080
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dnaic1b2b284Clo/Dnaic1b2b284Clo C57BL/6J-Dnaic1b2b284Clo MGI:5285345


Genotype
MGI:5285345
hm1
Allelic
Composition
Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic
Background
C57BL/6J-Dnaic1b2b284Clo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnaic1b2b284Clo mutation (1 available); any Dnaic1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Dextrocardia with parallel outflow tracts suggestive of DORV (confirmed by EFIC imaging).

cardiovascular system
• a spectrum of complex congenital heart disease is seen in conjunction with heterotaxy
• hypoplastic transverse arch
• multiple ventricular septal defects

growth/size/body
• heterotaxy where the left-right positioning of organs may be randomized (J:216862)

respiratory system
• airway cilia are missing the outer dynein arms

cellular
• cilia in tracheal epithelia show missing out dynein arm defect
• airway cilia are missing the outer dynein arms
• mice exhibit immotile/slow/dyskinetic cilia with little or no net fluid flow

mortality/aging
• mice that survive postnatally usually die from hydrocephalus by 5-10 days after birth

nervous system
• mice that survive postnatally usually die from hydrocephalus by 5-10 days after birth

Mouse Models of Human Disease
OMIM ID Ref(s)
Ciliary Dyskinesia, Primary, 1; CILD1 244400 J:175213





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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory