Mouse Genome Informatics
hm1
    Pink1tm1Hlw/Pink1tm1Hlw
involves: 129 * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• substantia nigras dopaminergic neurons exhibit mitochondrial fragmentation compared unlike wild-type neurons
• substantia nigras (SN) dopaminergic neurons are defective in maintaining mitochondrial membrane potential compared with wild-type cells
• SN dopaminergic neurons exhibit enhanced reactive oxygen species generation compared with wild-type cells

cellular
• substantia nigras neuronal cultures exhibit enhanced rotenone-induced cell death compared with similarly treated wild-type cultures
• substantia nigras dopaminergic neurons exhibit enhanced reactive oxygen species generation compared with wild-type cells