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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pink1tm1Hlw
targeted mutation 1, Hung-Li Wang
MGI:5142502
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pink1tm1Hlw/Pink1tm1Hlw involves: 129 * C57BL/6J MGI:5142505


Genotype
MGI:5142505
hm1
Allelic
Composition
Pink1tm1Hlw/Pink1tm1Hlw
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1Hlw mutation (0 available); any Pink1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• substantia nigras dopaminergic neurons exhibit mitochondrial fragmentation compared unlike wild-type neurons (J:175006)
• substantia nigras dopaminergic neurons exhibit mitochondrial fragmentation compared unlike wild-type neurons (J:175006)
• substantia nigras (SN) dopaminergic neurons are defective in maintaining mitochondrial membrane potential compared with wild-type cells (J:175006)
• SN dopaminergic neurons exhibit enhanced reactive oxygen species generation compared with wild-type cells (J:175006)
• substantia nigras (SN) dopaminergic neurons are defective in maintaining mitochondrial membrane potential compared with wild-type cells (J:175006)
• SN dopaminergic neurons exhibit enhanced reactive oxygen species generation compared with wild-type cells (J:175006)

cellular
• substantia nigras neuronal cultures exhibit enhanced rotenone-induced cell death compared with similarly treated wild-type cultures (J:175006)
• substantia nigras neuronal cultures exhibit enhanced rotenone-induced cell death compared with similarly treated wild-type cultures (J:175006)
• substantia nigras dopaminergic neurons exhibit enhanced reactive oxygen species generation compared with wild-type cells (J:175006)
• substantia nigras dopaminergic neurons exhibit enhanced reactive oxygen species generation compared with wild-type cells (J:175006)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory