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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pcp2-TBP*)69Hmhl
transgene insertion 69, Hsiu M Hsieh-Li
MGI:5142235
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Pcp2-TBP*)69Hmhl/0 involves: FVB/N MGI:5142236


Genotype
MGI:5142236
tg1
Allelic
Composition
Tg(Pcp2-TBP*)69Hmhl/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants exhibit clasping when held by the tail (J:174239)
• mutants exhibit clasping when held by the tail (J:174239)
• mutants exhibit ataxia beginning at 2 months of age (J:174239)
• mutants exhibit ataxia beginning at 2 months of age (J:174239)
• 2 and 4 month old mutants perform poorly on an accelerating rotarod and show continued declines in fall latency on the rod (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor improves rotatod performance (J:174239)
• 2 and 4 month old mutants perform poorly on an accelerating rotarod and show continued declines in fall latency on the rod (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor improves rotatod performance (J:174239)
• mutants rear more often during locomotor task than controls (J:174239)
• mutants rear more often during locomotor task than controls (J:174239)
• locomotor hyperactivity, with mutants moving significantly longer distances than controls (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor ameliorates locomotor hyperactivity (J:174239)
• locomotor hyperactivity, with mutants moving significantly longer distances than controls (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor ameliorates locomotor hyperactivity (J:174239)
• 3 month old mutants exhibit abnormal gait, with impaired step rhythm and reduction in step length compared to controls (J:174239)
• 3 month old mutants exhibit abnormal gait, with impaired step rhythm and reduction in step length compared to controls (J:174239)

nervous system
• marker analysis indicates an increase in inflammation in the cerebella (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor decreases inflammation (J:174239)
• marker analysis indicates an increase in inflammation in the cerebella (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor decreases inflammation (J:174239)
• brainstem is reduced compared to controls (J:174239)
• atrophy of the brainstem (J:174239)
• brainstem is reduced compared to controls (J:174239)
• atrophy of the brainstem (J:174239)
• cell loss in the globus pallidus of the subcortical region (J:174239)
• cell loss in the globus pallidus of the subcortical region (J:174239)
• cell loss in the caudate putamen (J:174239)
• cell loss in the caudate putamen (J:174239)
• cell loss in the accumbens nucleus (J:174239)
• cell loss in the accumbens nucleus (J:174239)
• subthalamic nucleus loss (J:174239)
• subthalamic nucleus loss (J:174239)
• cell loss in the cerebral cortex (J:174239)
• cell loss in the cerebral cortex (J:174239)
• atrophy of the cerebellum (J:174239)
• atrophy of the cerebellum (J:174239)
• Purkinje cell neurite loss (J:174239)
• Purkinje cell neurite loss (J:174239)
• Purkinje cell density is reduced along the Purkinje cell layer (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor increase in Purkinje dendritic complexity and cell numbers (J:174239)
• Purkinje cell density is reduced along the Purkinje cell layer (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor increase in Purkinje dendritic complexity and cell numbers (J:174239)
• Purkinje cell disruption in the molecular layer (J:174239)
• molecular layer is reduced (J:174239)
• Purkinje cell disruption in the molecular layer (J:174239)
• molecular layer is reduced (J:174239)
• loss of neurons in the dentate nucleus (J:174239)
• loss of neurons in the dentate nucleus (J:174239)
• cerebellar size is reduced (J:174239)
• mutants begin to show reduced cerebellar weight at 6 weeks of age (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor results in partial recovery of cerebellar size (J:174239)
• cerebellar size is reduced (J:174239)
• mutants begin to show reduced cerebellar weight at 6 weeks of age (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor results in partial recovery of cerebellar size (J:174239)
• reactive gliosis is seen in the cerebellum but not the brainstem (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor decreases gliosis (J:174239)
• reactive gliosis is seen in the cerebellum but not the brainstem (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor decreases gliosis (J:174239)
• loss of neurons in the dentate nucleus of the cerebellum (J:174239)
• cell loss in the cerebral cortex, caudate putamen, and globus pallidus of the subcortical region, and the accumbens nucleus (J:174239)
• loss of neurons in the dentate nucleus of the cerebellum (J:174239)
• cell loss in the cerebral cortex, caudate putamen, and globus pallidus of the subcortical region, and the accumbens nucleus (J:174239)
• atrophy and CA1 cell loss of the hippocampus (J:174239)
• atrophy and CA1 cell loss of the hippocampus (J:174239)

immune system
• marker analysis indicates an increase in inflammation in the cerebella (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor decreases inflammation (J:174239)
• marker analysis indicates an increase in inflammation in the cerebella (J:174239)
• treatment of mutants with granulocyte-colony stimulating factor decreases inflammation (J:174239)

Mouse Models of Human Disease
OMIM ID Ref(s)
Spinocerebellar Ataxia 17; SCA17 607136 J:174239





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory