All Phenotypes Slc17a6<tm2(cre)Lowl> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc17a6^tm2(cre)Lowl
targeted mutation 2, Bradford B Lowell
MGI:5141269

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rai1^tm2.1Luo/Rai1⁺ Slc17a6^tm2(cre)Lowl/?	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)	MGI:5817641
cn2	Rai1^tm2.1Luo/Rai1^tm2.1Luo Slc17a6^tm2(cre)Lowl/?	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)	MGI:5817637
cn3	Mc4r^tm2Lowl/Mc4r^tm2Lowl Slc17a6^tm2(cre)Lowl/Slc17a6⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5609673
cn4	Mc4r^tm1Lowl/Mc4r^tm1Lowl Slc17a6^tm2(cre)Lowl/Slc17a6⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5609677
cn5	Lepr^tm1.1Chua/Lepr^tm1.1Chua Slc17a6^tm2(cre)Lowl/Slc17a6⁺	involves: 129S6/SvEvTac	MGI:5142145

Allelic Composition	Rai1^tm2.1Luo/Rai1⁺ Slc17a6^tm2(cre)Lowl/?
Genetic Background	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:237687 )

• increased latency to fall in wire hang test

growth/size/body

increased body weight ( J:237687 )

• males and females exhibit 16% and 29% (respectively ) increased body weight as compared to controls

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Slc17a6^tm2(cre)Lowl/?
Genetic Background	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal associative learning ( J:237687 )

impaired contextual conditioning behavior ( J:237687 )

• decreased freezing behavior in contextual recall in trace fear-conditioning task

impaired cued conditioning behavior ( J:237687 )

• decreased freezing behavior in cued recall

impaired coordination ( J:237687 )

• increased time required to descend in pole test

• increased latency to fall in wire hang test

growth/size/body

obese ( J:237687 )

• males and females become obese at 9 and 7 weeks, respectively and are 56% (males) and 116% (females) heavier than controls at 20 weeks

Allelic Composition	Mc4r^tm2Lowl/Mc4r^tm2Lowl Slc17a6^tm2(cre)Lowl/Slc17a6⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4r^tm2Lowl mutation (0 available); any Mc4r mutation (44 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:216397 )

• increased fat mass

behavior/neurological

polyphagia ( J:216397 )

growth/size/body

obese ( J:216397 )

increased body length ( J:216397 )

Allelic Composition	Mc4r^tm1Lowl/Mc4r^tm1Lowl Slc17a6^tm2(cre)Lowl/Slc17a6⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4r^tm1Lowl mutation (2 available); any Mc4r mutation (44 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:216397 )

N	• rescue of the increased weight gain, of the fat stores, of hyperphagia and of the increased linear length seen in single Mc4r homozygotes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:216397 )

N	• mice show normalization of the hyperglycemia and hyperinsulinemia that is seen in single Mc4r homozygotes

respiratory system

respiratory system phenotype ( J:216397 )

N	• rescue of the depressed respiratory exchange ratio seen in single Mc4r homozygotes

Allelic Composition	Lepr^tm1.1Chua/Lepr^tm1.1Chua Slc17a6^tm2(cre)Lowl/Slc17a6⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.1Chua mutation (1 available); any Lepr mutation (121 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:174691 )

N	• animals do not show significant changes in body weight up to 11 weeks of age

behavior/neurological

behavior/neurological phenotype ( J:174691 )

N	• food intake shows no significant difference compared to controls

nervous system

nervous system phenotype ( J:174691 )

N	• deletion of Lepr in Slc17a6 neurons does not alter IPSC amplitude in Agrp neurons; IPSC frequency is decreased (not significantly) in Agrp • excitatory postsynaptic currents (sEPSCs and mEPSCs) in Pomc1 neurons are not affected by Lepr deletion in Slc17a6 (glutamatergic) neurons

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:174691 )

N	• fed and fasted blood glucose levels are unchanged and serum insulin levels are only slightly increased in the fed state

adipose tissue

adipose tissue phenotype ( J:174691 )

N	• no increase in fat mass is observed at 10 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23