All Phenotypes Snrpn<tm2.1Kaj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Snrpn^tm2.1Kaj
targeted mutation 2.1, Karen A Johnstone
MGI:5140864

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Snrpn^tm2.1Kaj/Snrpn⁺ Alpl^tm1(cre)Nagy/Alpl⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5140868

Allelic Composition	Snrpn^tm2.1Kaj/Snrpn⁺ Alpl^tm1(cre)Nagy/Alpl⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpl^tm1(cre)Nagy mutation (6 available); any Alpl mutation (351 available)
Snrpn^tm2.1Kaj mutation (1 available); any Snrpn mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:174457 )

• when the floxed allele is paternally inherited, only one mouse survived beyond P2 to die at P7

• however, mice that inherit the floxed allele maternally exhibit normal survival

growth/size/body

decreased birth weight ( J:174457 )

• when the floxed allele is paternally inherited

cellular

abnormal DNA methylation ( J:174457 )

• when the floxed allele is paternally inherited, DNA methylation at Mkrn3 and Ndn is increased compared to in wild-type mice

behavior/neurological

absent gastric milk in neonates ( J:174457 )

• when the floxed allele is paternally inherited

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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