Mouse Genome Informatics
hm1
    Ttc8tm1Reed/Ttc8tm1Reed
involves: 129
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• frequently die before weaning
• reduction of litter size and use of supplemental food and water improves survival

growth/size
• become obese with age
• effect is more pronounced in females
• detectable by P3
• however, by P70 body weights are similar to littermate controls

renal/urinary system
• mild dilation of tubules in the deep cortex

taste/olfaction
• dramatic loss of cilia with only scattered cilia seen above a surface of sustentacular cell microvilli
• fivefold reduction in odorant-evoked activity in an electro-olfactogram assay compared to littermate controls for multiple odorants

vision/eye

respiratory system
• dramatic loss of cilia with only scattered cilia seen above a surface of sustentacular cell microvilli

nervous system

craniofacial
• dramatic loss of cilia with only scattered cilia seen above a surface of sustentacular cell microvilli

Mouse Models of Human Disease
OMIM IDRef(s)
Bardet-Biedl Syndrome; BBS 209900 J:173465


Mouse Genome Informatics
cx2
    Olfr160tm4Mom/Olfr160+
Ttc8tm1Reed/Ttc8tm1Reed

involves: 129 * 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• impaired fasiculation of olfactory sensory neuron axons
• unlike in controls where all labeled axons converge to a single, posterior glomerulus, multiple glomeruli are innervated by olfactory sensory neuron axons and individual "wandering" fibers are observed

cellular
• impaired fasiculation of olfactory sensory neuron axons
• unlike in controls where all labeled axons converge to a single, posterior glomerulus, multiple glomeruli are innervated by olfactory sensory neuron axons and individual "wandering" fibers are observed


Mouse Genome Informatics
cx3
    Olfr17tm1Mom/Olfr17+
Ttc8tm1Reed/Ttc8tm1Reed

involves: 129 * 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• abnormal targeting of labeled olfactory sensory neuron axons is observed at P0

cellular
• abnormal targeting of labeled olfactory sensory neuron axons is observed at P0