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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ttc8tm1Reed
targeted mutation 1, Randall R Reed
MGI:5140723
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ttc8tm1Reed/Ttc8tm1Reed involves: 129 MGI:5140726
cx2
Olfr160tm4Mom/Olfr160+
Ttc8tm1Reed/Ttc8tm1Reed
involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:5140727
cx3
Olfr17tm1Mom/Olfr17+
Ttc8tm1Reed/Ttc8tm1Reed
involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:5140728


Genotype
MGI:5140726
hm1
Allelic
Composition
Ttc8tm1Reed/Ttc8tm1Reed
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttc8tm1Reed mutation (0 available); any Ttc8 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• dramatic loss of cilia with only scattered cilia seen above a surface of sustentacular cell microvilli

mortality/aging
• frequently die before weaning
• reduction of litter size and use of supplemental food and water improves survival

growth/size/body
• dramatic loss of cilia with only scattered cilia seen above a surface of sustentacular cell microvilli
• become obese with age
• effect is more pronounced in females
• detectable by P3
• however, by P70 body weights are similar to littermate controls

renal/urinary system
• mild dilation of tubules in the deep cortex

taste/olfaction
• dramatic loss of cilia with only scattered cilia seen above a surface of sustentacular cell microvilli
• fivefold reduction in odorant-evoked activity in an electro-olfactogram assay compared to littermate controls for multiple odorants

vision/eye

respiratory system
• dramatic loss of cilia with only scattered cilia seen above a surface of sustentacular cell microvilli

nervous system

craniofacial
• dramatic loss of cilia with only scattered cilia seen above a surface of sustentacular cell microvilli

Mouse Models of Human Disease
OMIM ID Ref(s)
Bardet-Biedl Syndrome 8; BBS8 615985 J:173465




Genotype
MGI:5140727
cx2
Allelic
Composition
Olfr160tm4Mom/Olfr160+
Ttc8tm1Reed/Ttc8tm1Reed
Genetic
Background
involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olfr160tm4Mom mutation (1 available); any Olfr160 mutation (18 available)
Ttc8tm1Reed mutation (0 available); any Ttc8 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• impaired fasiculation of olfactory sensory neuron axons
• unlike in controls where all labeled axons converge to a single, posterior glomerulus, multiple glomeruli are innervated by olfactory sensory neuron axons and individual "wandering" fibers are observed

cellular
• impaired fasiculation of olfactory sensory neuron axons
• unlike in controls where all labeled axons converge to a single, posterior glomerulus, multiple glomeruli are innervated by olfactory sensory neuron axons and individual "wandering" fibers are observed




Genotype
MGI:5140728
cx3
Allelic
Composition
Olfr17tm1Mom/Olfr17+
Ttc8tm1Reed/Ttc8tm1Reed
Genetic
Background
involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olfr17tm1Mom mutation (6 available); any Olfr17 mutation (16 available)
Ttc8tm1Reed mutation (0 available); any Ttc8 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• abnormal targeting of labeled olfactory sensory neuron axons is observed at P0

cellular
• abnormal targeting of labeled olfactory sensory neuron axons is observed at P0





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory