Analysis Tools
cellular
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• cell cycle is not arrested by gamma irradiation after treatment with adenovirus-cre
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Allele Symbol Allele Name Allele ID |
Trp53tm4Att targeted mutation 4, Laura D Attardi MGI:5140078 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cell cycle is not arrested by gamma irradiation after treatment with adenovirus-cre
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no apoptosis in mice treated with tamoxifen when measured 6 hours after radiation treatment
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after treatment with adenoviral cre, mice develop a significantly increased lung tumor burden unlike mice having mutations in only one of the two transactivation domains with normal tumor levels
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 83% of hearts exhibit outflow tract defects such as persistent truncus arteriosus and double outlet right ventricle
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• in 33% of E12.5 embryos
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• atrioventricular cushions fail to undergo remodeling
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• increase in apoptosis in the retina, neural crest cells, the thymus, neuroepithelium, and otic vesicles
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• decrease in proliferation in the retina, neural crest cells, the thymus, neuroepithelium, and otic vesicles
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• E13.5 or older embryos commonly exhibit craniofacial defects, including square-shaped faces, short lower jaws, cleft lip and cleft palate
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• short lower jaws 74% of embryos
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• square-shaped faces in some E13.5 or older embryos
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• in some E13.5 or older embryos
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• in some E13.5 or older embryos
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• protruding tongue due to short jaw
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• 41% of embryos exhibit defects in external ear formation
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• in some E13.5 or older embryos
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• protruding tongue due to short jaw
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• neural tube closure defects
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• square-shaped faces in some E13.5 or older embryos
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• in some E13.5 or older embryos
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• in some E13.5 or older embryos
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• protruding tongue due to short jaw
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• 41% of embryos exhibit defects in external ear formation
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• 41% of embryos exhibit defects in external ear formation
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• 71% of embryos exhibit a spectrum of inner ear defects, ranging from mild (either truncated posterior semi-circular canal or fused to the common crus) to highly abnormal (extreme inner ear bone malformation)
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• embryonic lethality between E13.5 and E15.5
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• neural tube closure defects
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• 63 % of E13.5 or older embryos exhibit exencephaly
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• kidneys show branching defects
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• short lower jaws 74% of embryos
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• reduction in bone density in the cranium, nasal cavity, ulna, humerus, mandible and femur
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• delay in bone formation in embryos
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• in 59% of embryos
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| CHARGE syndrome | DOID:0050834 |
OMIM:214800 |
J:217080 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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