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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Amer1tm1.2Nbar
targeted mutation 1.2, Nabeel Bardeesy
MGI:5086004
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Amer1tm1.2Nbar/Amer1+ involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL MGI:5086006
ot2
Amer1tm1.2Nbar/Y involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL MGI:5086005


Genotype
MGI:5086006
ht1
Allelic
Composition
Amer1tm1.2Nbar/Amer1+
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• less severe than in hemizygous mutant males (J:173242)
• less severe than in hemizygous mutant males (J:173242)
(J:173242)
(J:173242)

skeleton




Genotype
MGI:5086005
ot2
Allelic
Composition
Amer1tm1.2Nbar/Y
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
(J:173242)
(J:173242)

homeostasis/metabolism
(J:173242)
(J:173242)

cardiovascular system
• dramatic overgrowth (J:173242)
• dramatic overgrowth (J:173242)
(J:173242)
(J:173242)

growth/size/body
• hypoplastic adipose tissue (J:173242)
• hypoplastic adipose tissue (J:173242)
(J:173242)
(J:173242)
(J:173242)
(J:173242)

renal/urinary system
• kidneys may display agenesis or over growth, with both conditions often seen in the same animal (J:173242)
• unilateral or bilateral renal agenesis is seen in 64% of mice (J:173242)
• kidneys that do form have an expanded population of mesenchymal progenitor cells (J:173242)
• kidneys may display agenesis or over growth, with both conditions often seen in the same animal (J:173242)
• unilateral or bilateral renal agenesis is seen in 64% of mice (J:173242)
• kidneys that do form have an expanded population of mesenchymal progenitor cells (J:173242)
• the Wolffian duct remains detached from the ureteric bud at E13.5 in some mice (J:173242)
• absence of ureteric bud derived structures at E13.5 in some mice (J:173242)
• the Wolffian duct remains detached from the ureteric bud at E13.5 in some mice (J:173242)
• absence of ureteric bud derived structures at E13.5 in some mice (J:173242)
• expression analysis indicates that the metanephric mesenchyme is specified but fails to condense and undergo epithelialization (J:173242)
• expression analysis indicates that the metanephric mesenchyme is specified but fails to condense and undergo epithelialization (J:173242)
• widespread apoptosis is seen in many mice (J:173242)
• widespread apoptosis is seen in many mice (J:173242)
• kidneys that do form are significantly enlarged (J:173242)
• kidneys that do form are significantly enlarged (J:173242)
(J:173242)
(J:173242)
(J:173242)
(J:173242)
• absence of ureteric bud derived structures at E13.5 in some mice (J:173242)
• absence of ureteric bud derived structures at E13.5 in some mice (J:173242)

embryogenesis
• widespread apoptosis is seen in many mice (J:173242)
• widespread apoptosis is seen in many mice (J:173242)
• the Wolffian duct remains detached from the ureteric bud at E13.5 in some mice (J:173242)
• the Wolffian duct remains detached from the ureteric bud at E13.5 in some mice (J:173242)

skeleton
• dramatic bone overgrowth (J:173242)
• dramatic bone overgrowth (J:173242)
• malformation of the postnatal suture (J:173242)
• malformation of the postnatal suture (J:173242)
(J:173242)
(J:173242)
(J:173242)
(J:173242)
• enlarged cranial vault (J:173242)
• abnormally distant ossification fronts in the perinatal cranial vault (J:173242)
• enlarged cranial vault (J:173242)
• abnormally distant ossification fronts in the perinatal cranial vault (J:173242)
• discontinuous cortical bone layer at E15.5 (J:173242)
• discontinuous cortical bone layer at E15.5 (J:173242)
• malformed or absent (J:173242)
• malformed or absent (J:173242)
(J:173242)
(J:173242)
• enlarged and bowed (J:173242)
• enlarged and bowed (J:173242)
(J:173242)
(J:173242)
• enlarged and bowed (J:173242)
• enlarged and bowed (J:173242)
(J:173242)
(J:173242)
(J:173242)
(J:173242)
• asymmetrical distribution of ossification centers (J:173242)
• asymmetrical distribution of ossification centers (J:173242)
• massive increases in mineralized matrix (J:173242)
• massive increases in mineralized matrix (J:173242)
(J:173242)
(J:173242)
• decreased mineralization of the trabecular area in long bones perinatally (J:173242)
• massive increases in mineralized matrix in the compact bone (J:173242)
• decreased mineralization of the trabecular area in long bones perinatally (J:173242)
• massive increases in mineralized matrix in the compact bone (J:173242)
• deficiency in endochondral bone ossification (J:173242)
• deficiency in endochondral bone ossification (J:173242)
• delayed ossification of the long bones at E14.5 (J:173242)
• discontinuous cortical bone layer in long bones at E15.5 (J:173242)
• delayed ossification of the long bones at E14.5 (J:173242)
• discontinuous cortical bone layer in long bones at E15.5 (J:173242)
• deficiency in intramembranous bone ossification (J:173242)
• deficiency in intramembranous bone ossification (J:173242)
• abnormally distant ossification fronts in the perinatal cranial vault (J:173242)
• abnormally distant ossification fronts in the perinatal cranial vault (J:173242)

adipose tissue
• severely reduced (J:173242)
• severely reduced (J:173242)
• severely reduced (J:173242)
• severely reduced (J:173242)
• hypoplastic adipose tissue (J:173242)
• hypoplastic adipose tissue (J:173242)

hematopoietic system
(J:173242)
(J:173242)

immune system
(J:173242)
(J:173242)

craniofacial
• malformation of the postnatal suture (J:173242)
• malformation of the postnatal suture (J:173242)
(J:173242)
(J:173242)
(J:173242)
(J:173242)
• enlarged cranial vault (J:173242)
• abnormally distant ossification fronts in the perinatal cranial vault (J:173242)
• enlarged cranial vault (J:173242)
• abnormally distant ossification fronts in the perinatal cranial vault (J:173242)

limbs/digits/tail
• malformed or absent (J:173242)
• malformed or absent (J:173242)
(J:173242)
(J:173242)
• enlarged and bowed (J:173242)
• enlarged and bowed (J:173242)
(J:173242)
(J:173242)
• enlarged and bowed (J:173242)
• enlarged and bowed (J:173242)
(J:173242)
(J:173242)

cellular
• widespread apoptosis is seen in many mice (J:173242)
• widespread apoptosis is seen in many mice (J:173242)

Mouse Models of Human Disease
OMIM ID Ref(s)
Osteopathia Striata with Cranial Sclerosis; OSCS 300373 J:173242





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory