Mouse Genome Informatics
ht1
    Shank3tm1.1Pfw/Shank3+
B6.129S6-Shank3tm1.1Pfw
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• mice exhibit normal short-term spatial recognition, spatial working memory, context and cue-related fear memory and extinction, anxiety levels, and learning of motor skills (J:198768)
• mice exhibit lower amplitudes and longer latencies of startle response compared with wild-type mice
• in dizocilpine- or amphetamine-treated mice
• however, mice do not exhibit novelty-induced hyperactivity
• mice exhibit reduced social investigation modulated by episodes of aggression compared with wild-type mice
• mice exhibit increased aggression towards a novel stimulus mouse and in a resident-intruder tests compared with wild-type mice
• mice exhibit reduced social investigation modulated by episodes of aggression compared with wild-type mice
• male mice spend more time investigating an enclosed male stimulus compared with wild-type mice
• male mice exhibit increased latency to approach a sexually receptive enclosed female mouse compared with wild-type mice
• however, mice exhibit normal social recognition memory
• male mice exhibit latency to first ultrasound call in the presence of a female mice compared with wild-type mice

nervous system
• the ratio of NMDA to AMPA-dependent response in the cortex is reduced compared to in wild-type mice
• however, AMPAR-mediated miniature excitatory postsynaptic current amplitude and frequency are normal
• NMDAR-dependent long term potentiation induction magnitude is reduced and decays more rapidly than in wild-type mice
• glutamate receptor long term depression (mGluR-LTD) induced by DHPG is increased and inhibited by cycloheximide compared to in wild-type mice
• LTD induced by paired-pulse low-frequency stimulation is increased compared to in wild-type mice
• NMDAR-dependent long term depression of Schaffer collateral-CA1 synapses is reduced compared to in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Autism 209850 J:198768