Mouse Genome Informatics
hm1
    Shank3tm1Yhj/Shank3tm1Yhj
B6.129S7-Shank3tm1Yhj
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• mice exhibit normal prepulse inhibition, startle response, anxiety related behavior in a light-dark emergence test and elevated zero maze, novel object recognition, and social transmission of food preference (J:173402)
• male mice exhibit impaired motor learning on a rotarod compared with wild-type mice
• however, female mice exhibit normal motor learning
• mice exhibit decreased novel object preference compared with wild-type mice
• during long term and remote memory tests, mice exhibit more object contacts than wild-type mice
• in Morris water maze due to test familiarization or delayed learning, rather than specific sensory, motor, or motivational abnormalities
• mice exhibit reduced orienting to moving objects compared with wild-type mice
• mice exhibit decreased darting compared with wild-type mice
• in male mice tip-over in a vertical placement test compared with wild-type mice
• mice exhibit impaired climbing down a vertical pole compared with wild-type mice
• in a foot-misplacement test, mice exhibit increased foot-fault compared with wild-type mice
• male mice exhibit more severe impairments than female mice
• in male mice, but not female mice
• in male mice, but not female mice
• as detected by a treadscan gait analysis, mice exhibit increased stance and brake time and diagonal coupling ratio compared with wild-type mice
• in a hole-board test, mice exhibit more head pokes compared with wild-type mice
• when encountering a novel object in a familiar environment, mice exhibit stereotypic investigation and self-stimulatory behavior compared with wild-type mice
• mice fail to show social affiliation compared with wild-type mice
• mice exhibit reduced social behavior in a dyadic test and elicit less social interaction from C3H partner mice compared with wild-type mice
• mice exhibit reduced time sniffing compared with wild-type mice
• however, mice prefer interacting with a novel animal when forced to choose between two social stimuli in the social preference test
• mice exhibit aberrant duration and frequency of ultrasonic vocalizations compared with wild-type mice

nervous system
N
• brain weight is normal at 2 to 4 months of age (J:173402)
• mice exhibit normal basal synaptic transmission (J:173402)
• at 4 weeks of age, spines are less dense and longer than in wild-type mice
• at 10 weeks, spine length is increased compared to in wild-type mice
• however, spine density at 10 weeks of age is normal
• mice exhibit impaired hippocampal CA1 synaptic plasticity compared with wild-type mice

growth/size/body
• slightly at 8 to 12 months
• however, body weight is normal at 3 to 4 months of age

taste/olfaction
N
• mice exhibit normal olfaction (J:173402)

Mouse Models of Human Disease
OMIM IDRef(s)
Autism 209850 J:173402