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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pdgfra-cre/ERT)467Dbe
transgene insertion 467, Dwight E Bergles
MGI:5056164
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Tg(Pdgfra-cre/ERT)467Dbe/0
involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:7494131
cn2
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Tg(Pdgfra-cre/ERT)467Dbe/0
involves: 129X1/SvJ * C57BL/6 * SJL MGI:6197799


Genotype
MGI:7494131
cn1
Allelic
Composition
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Tg(Pdgfra-cre/ERT)467Dbe/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7tm1.1Dmm mutation (1 available); any Chd7 mutation (136 available)
Tg(Pdgfra-cre/ERT)467Dbe mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decrease in the number of oligodendrocyte precursor cells in the corpus callosum and cortex at P7
• however, proliferation of oligodendrocyte precursor cells is similar to controls
• marked reduction in differentiating oligodendrocytes in cortical regions at 11 days after induction of cre expression (J:234565)
• while the recruitment of oligodendrocyte precursors to sites of lysolecithin-induced demyelination is similar to controls, the number of oligodendrocyte lineage cells are substantially reduced at these sites resulting in reduced remyelination (J:234565)
• decrease in the number of immature oligodendrocytes and expression changes indicates impaired ability to begin differentiation (J:264451)
• apoptotic oligodendrocyte precursor cells are seen in P7 brains but are rarely seen in controls

cellular
• decrease in the number of oligodendrocyte precursor cells in the corpus callosum and cortex at P7
• however, proliferation of oligodendrocyte precursor cells is similar to controls
• apoptotic oligodendrocyte precursor cells are seen in P7 brains but are rarely seen in controls




Genotype
MGI:6197799
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Tg(Pdgfra-cre/ERT)467Dbe/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Pdgfra-cre/ERT)467Dbe mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• tamoxifen-treated mice show reduced density of alveoli
• alveoli are enlarged in tamoxifen-treated mice
• tamoxifen-treated mice exhibit emphysematous changes including enlarged alveoli with reduced alveolar density





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory