All Phenotypes Sfrp4<tm1.1Blan> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan	involves: C57BL/6	MGI:5052062
hm2	Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan	Not Specified	MGI:5790177
ht3	Sfrp4^tm1.1Blan/Sfrp4⁺	Not Specified	MGI:5790179
cx4	Fgf23^tm1Blan/Fgf23^tm1Blan Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan	involves: 129 * C57BL/6	MGI:5052063
cx5	Kl^tm1Lex/Kl^tm1Lex Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan	involves: 129S/SvEvBrd * C57BL/6	MGI:5052065

Allelic Composition	Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp4^tm1.1Blan mutation (0 available); any Sfrp4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reduced female fertility ( J:173962 )

• female mice produced slightly smaller litters compared with heterozygous mice

decreased litter size ( J:173962 )

• female mice produced slightly smaller litters compared with heterozygous mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:173962 )

N	• mice exhibit normal serum phosphate and calcium levels and urinary phosphate/creatinine levels

growth/size/body

growth/size/body region phenotype ( J:173962 )

N	• mice exhibit normal body size

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased osteoclast cell number ( J:234467 )

• the number of osteoclasts is increased along the diaphyseal endocortical surface

• however, number of osteoclasts is normal in trabecular bone

• in 8 day growing mice, the number of osteoclasts along the endosteum is increased

abnormal long bone metaphysis morphology ( J:234467 )

• expanded metaphyses

increased diameter of long bones ( J:234467 )

• width of bones at the midshaft is increased

increased trabecular bone volume ( J:234467 )

decreased compact bone thickness ( J:234467 )

• thin cortical bone in femora and tibiae in 2 week old mice

• thin cortical bone in the calvaria

• treatment with a sclerostin-neutralizing antibody increases cortical bone thickness

decreased femur compact bone thickness ( J:234467 )

abnormal bone ossification ( J:234467 )

• decrease in cortical bone formation

abnormal bone mineralization ( J:234467 )

• rates of periosteal and endocortical mineral apposition are equally reduced

increased bone ossification ( J:234467 )

• increase in bone-formation rates

abnormal bone remodeling ( J:234467 )

• failure of bone remodeling during growth

increased bone resorption ( J:234467 )

• increase in endocortical bone resorption

decreased bone strength ( J:234467 )

• reduction in mechanical strength measured at the diaphysis

hematopoietic system

increased osteoclast cell number ( J:234467 )

• the number of osteoclasts is increased along the diaphyseal endocortical surface

• however, number of osteoclasts is normal in trabecular bone

• in 8 day growing mice, the number of osteoclasts along the endosteum is increased

immune system

increased osteoclast cell number ( J:234467 )

• the number of osteoclasts is increased along the diaphyseal endocortical surface

• however, number of osteoclasts is normal in trabecular bone

• in 8 day growing mice, the number of osteoclasts along the endosteum is increased

limbs/digits/tail

decreased femur compact bone thickness ( J:234467 )

Allelic Composition	Sfrp4^tm1.1Blan/Sfrp4⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp4^tm1.1Blan mutation (0 available); any Sfrp4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased trabecular bone volume ( J:234467 )

decreased compact bone thickness ( J:234467 )

• decrease in cortical thickness

• treatment with a soluble Bmp2 receptor, RAP-661, increases cortical bone thickness

abnormal bone mineralization ( J:234467 )

• rates of periosteal and endocortical mineral apposition are equally reduced

Allelic Composition	Fgf23^tm1Blan/Fgf23^tm1Blan Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf23^tm1Blan mutation (0 available); any Fgf23 mutation (16 available)
Sfrp4^tm1.1Blan mutation (0 available); any Sfrp4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:173962 )

• average life span is 8 to 12 weeks

homeostasis/metabolism

increased circulating phosphate level ( J:173962 )

renal/urinary system

nephrocalcinosis ( J:173962 )

respiratory system

emphysema ( J:173962 )

digestive/alimentary system

abnormal digestive system morphology ( J:173962 )

• mice exhibit intestinal atrophy unlike wild-type mice

cardiovascular system

calcified artery ( J:173962 )

growth/size/body

decreased body size ( J:173962 )

• at 3 and 6 weeks

Allelic Composition	Kl^tm1Lex/Kl^tm1Lex Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan
Genetic Background	involves: 129S/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kl^tm1Lex mutation (1 available); any Kl mutation (53 available)
Sfrp4^tm1.1Blan mutation (0 available); any Sfrp4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:173962 )

• average life span is 14 to 16 weeks

homeostasis/metabolism

increased circulating phosphate level ( J:173962 )

digestive/alimentary system

abnormal digestive system morphology ( J:173962 )

• mice exhibit intestinal atrophy unlike wild-type mice

respiratory system

emphysema ( J:173962 )

renal/urinary system

nephrocalcinosis ( J:173962 )

cardiovascular system

calcified artery ( J:173962 )

growth/size/body

decreased body size ( J:173962 )

• at 3 and 6 weeks

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