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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Birc2tm1Rbr
targeted mutation 1, Robert Brink
MGI:5013654
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1Rbr/Birc3tm1Rbr
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 * NZB MGI:5013716
cn2
 		Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 * NZB MGI:5013717
cn3
 		Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Cd19tm1(cre)Cgn/Cd19+
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass 		involves: 129P2/OlaHsd * C57BL/6 * NZB MGI:5013718
cx4
 		Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1Rbr/Birc3tm1Rbr 		involves: C57BL/6 MGI:5319371
cx5
 		Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr 		involves: C57BL/6 * NZB MGI:5013715
cx6
 		Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr 		involves: C57BL/6 * SJL MGI:5319373


Genotype
MGI:5013716
cn1
Allelic
Composition		 Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1Rbr/Birc3tm1Rbr
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3tm1Rbr mutation (0 available); any Birc3 mutation (31 available)
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:172843 )
N
• mice exhibit no differences in spleen or lymph node size or in the numbers or phenotype of the B cells within these peripheral lymphoid tissues compared with wild-type mice




Genotype
MGI:5013717
cn2
Allelic
Composition		 Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3tm1.1Rbr mutation (0 available); any Birc3 mutation (31 available)
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased germinal center B cell number ( J:172843 )
• in response to CD40L, mice exhibit 10-fold lower germinal center B cells compared with wild-type mice
increased B cell number ( J:172843 )
• in the lymph nodes, follicular, and marginal zone
decreased spleen germinal center size ( J:172843 )
• in response to CD40L

hematopoietic system
decreased germinal center B cell number ( J:172843 )
• in response to CD40L, mice exhibit 10-fold lower germinal center B cells compared with wild-type mice
increased B cell number ( J:172843 )
• in the lymph nodes, follicular, and marginal zone
decreased spleen germinal center size ( J:172843 )
• in response to CD40L

cellular

growth/size/body
enlarged spleen ( J:172843 )




Genotype
MGI:5013718
cn3
Allelic
Composition		 Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Cd19tm1(cre)Cgn/Cd19+
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3tm1.1Rbr mutation (0 available); any Birc3 mutation (31 available)
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:172843 )
N
• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13ctm1Mass homozygotes




Genotype
MGI:5319371
cx4
Allelic
Composition		 Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1Rbr/Birc3tm1Rbr
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3tm1Rbr mutation (0 available); any Birc3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5013715
cx5
Allelic
Composition		 Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Genetic
Background		 involves: C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3tm1.1Rbr mutation (0 available); any Birc3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:172843 )
N
• mice exhibit no differences in spleen or lymph node size or in the numbers or phenotype of the B cells within these peripheral lymphoid tissues compared with wild-type mice




Genotype
MGI:5319373
cx6
Allelic
Composition		 Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3tm1.1Rbr mutation (0 available); any Birc3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:182515 )
• mice are viable with no reproductive or developmental defects




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory