About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Panx1tm1.2Vmd
targeted mutation 1.2, Vishva M Dixit
MGI:5013648
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Panx1tm1.2Vmd/Panx1tm1.2Vmd C57BL/6N-Panx1tm1.2Vmd MGI:5013649


Genotype
MGI:5013649
hm1
Allelic
Composition
Panx1tm1.2Vmd/Panx1tm1.2Vmd
Genetic
Background
C57BL/6N-Panx1tm1.2Vmd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx1tm1.2Vmd mutation (0 available); any Panx1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• macrophage exhibit normal assembly of caspase-1-activating inflammosome complexes
• thymocytes cultured with dexamethasone to induce apoptosis exhibit reduced YO-PRO-1 dye uptake and fail to release ATP unlike similarly treated wild-type cells
• apoptotic thymocytes fail to recruit macrophages in a transwell migration assay unlike wild-type cells
• however, thymocyte apoptosis is normal

hematopoietic system
• thymocytes cultured with dexamethasone to induce apoptosis exhibit reduced YO-PRO-1 dye uptake and fail to release ATP unlike similarly treated wild-type cells
• apoptotic thymocytes fail to recruit macrophages in a transwell migration assay unlike wild-type cells
• however, thymocyte apoptosis is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory