Phenotypes associated with this allele

• Allele Symbol: Abcc10^tm1Eah
• Allele Name: targeted mutation 1, Elizabeth A Hopper-Borge
• Allele ID: MGI:5013608
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcc10^tm1Eah/Abcc10^tm1Eah	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5013618

Genotype
MGI:5013618

hm1

• Allelic Composition: Abcc10^tm1Eah/Abcc10^tm1Eah
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:172648 )

• in paclitaxel-treated mice

immune system

thymus cortex hypoplasia ( J:172648 )

• in paclitaxel-treated mice, the cortex of thymus is decreased in size due to increased lymphocyte apoptosis and/or depopulation compared to in wild-type mice

decreased leukocyte cell number ( J:172648 )

• in female mice treated with paclitaxel

abnormal spleen red pulp morphology ( J:172648 )

• paclitaxel-treated mice exhibit decreased erythroid and myeloid cell proliferation, which are replaced with histocytes and stromal cells, compared to in similarly treated wild-type mice

small spleen ( J:172648 )

• in paclitaxel-treated mice

decreased spleen germinal center number ( J:172648 )

• in paclitaxel-treated mice

decreased spleen germinal center size ( J:172648 )

• in paclitaxel-treated mice

decreased spleen white pulp amount ( J:172648 )

• in paclitaxel-treated mice

growth/size/body

decreased body weight ( J:172648 )

• in female mice treated with paclitaxel

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:172648 )

• paclitaxel-treated mice exhibit increased mortality, decreased body weight, decreased white blood cells, and hypoplasia of the bone marrow, spleen, and thymus compared with wild-type mice

hematopoietic system

thymus cortex hypoplasia ( J:172648 )

• in paclitaxel-treated mice, the cortex of thymus is decreased in size due to increased lymphocyte apoptosis and/or depopulation compared to in wild-type mice

decreased bone marrow cell number ( J:172648 )

• in paclitaxel-treated mice

decreased leukocyte cell number ( J:172648 )

• in female mice treated with paclitaxel

abnormal spleen red pulp morphology ( J:172648 )

• paclitaxel-treated mice exhibit decreased erythroid and myeloid cell proliferation, which are replaced with histocytes and stromal cells, compared to in similarly treated wild-type mice

small spleen ( J:172648 )

• in paclitaxel-treated mice

decreased spleen germinal center number ( J:172648 )

• in paclitaxel-treated mice

decreased spleen germinal center size ( J:172648 )

• in paclitaxel-treated mice

decreased spleen white pulp amount ( J:172648 )

• in paclitaxel-treated mice

endocrine/exocrine glands

thymus cortex hypoplasia ( J:172648 )

• in paclitaxel-treated mice, the cortex of thymus is decreased in size due to increased lymphocyte apoptosis and/or depopulation compared to in wild-type mice