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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adamts4tm1.1Boer
targeted mutation 1.1, Derek Boerboom
MGI:5009124
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adamts4tm1.1Boer/Adamts4tm1.1Boer involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:5009126
cx2
 		Adamts1tm1Mapr/Adamts1tm1Mapr
Adamts4tm1.1Boer/Adamts4tm1.1Boer 		involves: 129 * BALB/cJ * C57BL/6J MGI:5009127


Genotype
MGI:5009126
hm1
Allelic
Composition		 Adamts4tm1.1Boer/Adamts4tm1.1Boer
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts4tm1.1Boer mutation (0 available); any Adamts4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:172645 )
• viable and fertile with no gross abnormalities




Genotype
MGI:5009127
cx2
Allelic
Composition		 Adamts1tm1Mapr/Adamts1tm1Mapr
Adamts4tm1.1Boer/Adamts4tm1.1Boer
Genetic
Background		 involves: 129 * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts1tm1Mapr mutation (2 available); any Adamts1 mutation (64 available)
Adamts4tm1.1Boer mutation (0 available); any Adamts4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:172645 )
• more than 95% of mice die within 72 hours of birth
• mice that survive past 72 hours live to adulthood

renal/urinary system
renal/urinary system phenotype ( J:172645 )
N
• morphology of the renal cortex is essentially normal
kidney medulla atrophy ( J:172645 )
• irregularly and markedly thinned in newborns and the few surviving adults
hydronephrosis ( J:172645 )
• the renal pelvis is dilated in newborns and the few surviving adults
• no signs of urinary tract obstruction are detected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory