cardiovascular system
|
• vascular smooth muscle cell abnormalities with intracellular inclusions are seen at 6 months of age
|
homeostasis/metabolism
|
• increased susceptibility to ischemic injury seen in Notch3 null mice is not rescued by expression of the mutant human NOTCH3
|
muscle
|
• vascular smooth muscle cell abnormalities with intracellular inclusions are seen at 6 months of age
|
nervous system
|
• increased susceptibility to ischemic injury seen in Notch3 null mice is not rescued by expression of the mutant human NOTCH3
|
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Cerebral Arteriopathy, Autosomal Dominant, with Subcortical Infarcts and Leukoencephalopathy; CADASIL | 125310 | J:171887 | |