Mouse Genome Informatics
cn1
    Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/Gt(ROSA)26Sor+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Tagln-cre)1Her/0

involves: 129 * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• increased susceptibility to ischemic injury seen in Notch3 null mice is not rescued by expression of the mutant human NOTCH3 at 1 year of age but is rescued at 3 to 6 months of age

nervous system
• increased susceptibility to ischemic injury seen in Notch3 null mice is not rescued by expression of the mutant human NOTCH3 at 1 year of age but is rescued at 3 to 6 months of age


Mouse Genome Informatics
cn2
    Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/Gt(ROSA)26Sor+
Tg(Tagln-cre)1Her/0

involves: 129S2/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• thinning of the vascular smooth muscle layers
• osmiophilic granular deposits in mice older than 12 months of age
• vascular smooth muscle cell abnormalities with intracellular inclusions and lipid droplets that get more severe with age
• thinning of the vascular smooth muscle layers

muscle
• vascular smooth muscle cell abnormalities with intracellular inclusions and lipid droplets that get more severe with age
• thinning of the vascular smooth muscle layers

nervous system
• osmiophilic granular deposits in mice older than 12 months of age