Phenotypes associated with this allele

• Allele Symbol: Hsd17b14^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007181
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsd17b14^tm1Lex/Hsd17b14^tm1Lex	B6;129S5-Hsd17b14^tm1Lex/Mmucd	MGI:5882203

Genotype
MGI:5882203

hm1

• Allelic Composition: Hsd17b14^tm1Lex/Hsd17b14^tm1Lex
• Genetic Background: B6;129S5-Hsd17b14^tm1Lex/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased response to stress-induced hyperthermia ( J:171883 )

♂ • male homozygous mutants show an increased anxiety-like response during stress-induced hyperthermia testing when compared with controls

cellular

oligozoospermia ( J:171883 )

♂ • male homozygous mutant mice show decreased sperm production

endocrine/exocrine glands

testis degeneration ( J:171883 )

♂ • male homozygous mutant mice show vacuolar degeneration in the testes

hematopoietic system

increased IgG2a level ( J:171883 )

• homozygous mutant mice exhibited an increased mean serum IgG2a response to ovalbumin challenge

homeostasis/metabolism

increased response to stress-induced hyperthermia ( J:171883 )

♂ • male homozygous mutants show an increased anxiety-like response during stress-induced hyperthermia testing when compared with controls

immune system

increased IgG2a level ( J:171883 )

• homozygous mutant mice exhibited an increased mean serum IgG2a response to ovalbumin challenge

reproductive system

oligozoospermia ( J:171883 )

♂ • male homozygous mutant mice show decreased sperm production

testis degeneration ( J:171883 )

♂ • male homozygous mutant mice show vacuolar degeneration in the testes

male infertility ( J:171883 )

♂ • male homozygous mutant mice show infertility in the mutants