All Phenotypes Erfe<tm1Lex> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erfe^tm1Lex/Erfe^tm1Lex	B6;129S5-Erfe^tm1Lex/Mmucd	MGI:5582245
ht2	Erfe^tm1Lex/Erfe⁺	B6;129S5-Erfe^tm1Lex/Mmucd	MGI:5582252
cx3	Erfe^tm1Lex/Erfe^tm1Lex Hbb-b1^tm1Unc/Hbb-b1⁺ Hbb-b2^tm1Unc/Hbb-b2⁺	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6	MGI:5582255

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased hematocrit ( J:211331 )

• following phlebotomy, 12 week old mice show lower hematocrit levels compared to wild-type mice

decreased hemoglobin content ( J:211331 )

• mildly lower hemoglobin concentration at 6 weeks of age

• following phlebotomy, 12 week old mice show lower hemoglobin concentrations

• however, hematological parameters are normal at 3, 12, and 24 weeks of age and liver iron or hepcidin concentrations and spleen iron content are normal

decreased mean corpuscular hemoglobin ( J:211331 )

• following phlebotomy, 12 week old mice show lower mean corpuscular hemoglobin levels

decreased mean corpuscular hemoglobin concentration ( J:211331 )

• mildly lower mean corpuscular hemoglobin concentration at 6 weeks of age

decreased mean corpuscular volume ( J:211331 )

• mice exhibit an insignificant trend toward lower mean corpuscular volume at 6, 12, and 24 week of age, however following phlebotomy, 12 week old mice show a significant decrease in mean corpuscular volume

homeostasis/metabolism

decreased circulating iron level ( J:211331 )

• mice exhibit an insignificant trend toward lower serum iron levels at 6, 12, and 24 weeks of age, however after phlebotomy, mice show serum iron concentrations significantly lower than at baseline at all time points examined

increased susceptibility to injury ( J:211331 )

• recovery of 12 week old mice from hemorrhage-induced anemia (phlebotomy) is delayed by several days

liver/biliary system

abnormal liver physiology ( J:211331 )

• 6 week old mice fail to suppress hepatic expression of hepcidin mRNA in response to phlebotomy as seen in wild-type mice

• however, erythroblast differentiation is normal after phlebotomy

Allelic Composition	Erfe^tm1Lex/Erfe⁺
Genetic Background	B6;129S5-Erfe^tm1Lex/Mmucd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erfe^tm1Lex mutation (2 available); any Erfe mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased hemoglobin content ( J:211331 )

• slight decrease in hemoglobin levels

liver/biliary system

abnormal liver physiology ( J:211331 )

• 6 week old mice show a blunted hepatic suppression of hepcidin to phlebotomy compared to wild-type mice

Allelic Composition	Erfe^tm1Lex/Erfe^tm1Lex Hbb-b1^tm1Unc/Hbb-b1⁺ Hbb-b2^tm1Unc/Hbb-b2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erfe^tm1Lex mutation (2 available); any Erfe mutation (12 available)
Hbb-b1^tm1Unc mutation (2 available); any Hbb-b1 mutation (7 available)
Hbb-b2^tm1Unc mutation (2 available); any Hbb-b2 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mean corpuscular hemoglobin ( J:211331 )

• mean corpuscular hemoglobin levels are decreased compared to double heterozygous Hbb-b1^tm1Unc and Hbb-b2^tm1Unc mutants

decreased mean corpuscular volume ( J:211331 )

• erythrocyte mean corpuscular volume is decreased compared to double heterozygous Hbb-b1^tm1Unc and Hbb-b2^tm1Unc mutants

homeostasis/metabolism

decreased circulating iron level ( J:211331 )

• serum iron concentrations are decreased compared to double heterozygous Hbb-b1^tm1Unc and Hbb-b2^tm1Unc mutants

abnormal hormone level ( J:211331 )

• increase in hepcidin levels

decreased liver iron level ( J:211331 )

• mice show less hepatic iron overload than double heterozygous Hbb-b1^tm1Unc and Hbb-b2^tm1Unc mutants

liver/biliary system

decreased liver iron level ( J:211331 )

• mice show less hepatic iron overload than double heterozygous Hbb-b1^tm1Unc and Hbb-b2^tm1Unc mutants

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